UniProt P04839
Cytochrome b-245 heavy chain (P04839)
Cytochrome b-245 heavy chain (UniProt P04839), EC 1.-.-.-: 7 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P04839
- Protein
- Cytochrome b-245 heavy chain
- EC
- 1.-.-.-
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 41 · 5 records with a druggable one
Structures
8 records of P04839 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3A1F | The crystal structure of NADPH binding domain of gp91(phox) | x-ray diffraction | A | — | — |
| 3A1F | The crystal structure of NADPH binding domain of GP91(PHOX) | x-ray diffraction | A | — | — |
| 7U8G | Cryo-EM structure of the core human NADPH oxidase NOX2 | electron microscopy | A | POV, NAG, HEM | 2 (best 0.85) |
| 8GZ3 | Structure of human phagocyte NADPH oxidase in the resting state | electron microscopy | B | NAG, FAD, HEM, LBN | 8 (best 0.82) |
| 8KEI | Cryo-EM structure of NADPH oxidase 2 in complex with p22phox and EROS | electron microscopy | B | NAG, POV, HEM, LBN | 15 (best 0.81) |
| 8WEJ | Structure of human phagocyte NADPH oxidase in the activated state | electron microscopy | B | NAG, HEM, MG, NDP, FDA | 8 (best 0.82) |
| 8X2L | Structure of human phagocyte NADPH oxidase in the resting state in the presence of 2 mM NADPH | electron microscopy | B | NAG, FAD, HEM, MG | 8 (best 0.82) |
| P04839 | AlphaFold monomer V2.0 prediction for cytochrome B-245 heavy chain (P04839) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- FAD · Flavin-adenine dinucleotide · in 2 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 2 records
- MG · Magnesium ion · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- FDA · Dihydroflavine-adenine dinucleotide · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
Experiment against prediction
- 8WEJ chain B against the predicted model P04839: TM-score 0.98, RMSD 1.24 Å
- 7U8G chain A against the predicted model P04839: TM-score 0.98, RMSD 0.94 Å
- 3A1F chain A against the predicted model P04839: TM-score 0.90, RMSD 1.91 Å
- 3A1F chain A against the predicted model P04839: TM-score 0.90, RMSD 1.91 Å
- 8X2L chain B against the predicted model P04839: TM-score 0.90, RMSD 2.95 Å
- 8GZ3 chain B against the predicted model P04839: TM-score 0.88, RMSD 3.27 Å
- 8KEI chain B against the predicted model P04839: TM-score 0.54, RMSD 5.26 Å
Elsewhere
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