UniProt P04035
P04035
P04035 (UniProt P04035): 44 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04035
- Experimental structures
- 44
- Predicted models
- 1
Structures
45 records of P04035 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DQ8 | Complex of the catalytic portion of human hmg-CoA reductase with hmg and CoA | x-ray diffraction | A, B, C, D | — | — |
| 1DQ8 | Complex of the catalytic portion of human hmg-CoA reductase with hmg and CoA | x-ray diffraction | A, B, C, D | — | — |
| 1DQ9 | Complex of catalytic portion of human hmg-CoA reductase with hmg-CoA | x-ray diffraction | A, B, C, D | — | — |
| 1DQ9 | Complex of catalytic portion of human hmg-CoA reductase with hmg-CoA | x-ray diffraction | A, B, C, D | — | — |
| 1DQA | Complex of the catalytic portion of human hmg-CoA reductase with hmg, CoA, and NADP+ | x-ray diffraction | A, B, C, D | — | — |
| 1DQA | Complex of the catalytic portion of human hmg-CoA reductase with hmg, CoA, and NADP+ | x-ray diffraction | A, B, C, D | — | — |
| 1HW8 | Complex of the catalytic portion of human hmg-CoA reductase with compactin (also known as… | x-ray diffraction | A, B, C, D | — | — |
| 1HW8 | Complex of the catalytic portion of human hmg-CoA reductase with compactin (also known as… | x-ray diffraction | A, B, C, D | — | — |
| 1HW9 | Complex of the catalytic portion of human hmg-CoA reductase with simvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HW9 | Complex of the catalytic portion of human hmg-CoA reductase with simvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWI | Complex of the catalytic portion of human hmg-CoA reductase with fluvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWI | Complex of the catalytic portion of human hmg-CoA reductase with fluvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWJ | Complex of the catalytic portion of human hmg-CoA reductase with cerivastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWJ | Complex of the catalytic portion of human hmg-CoA reductase with cerivastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWK | Complex of the catalytic portion of human hmg-CoA reductase with atorvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWK | Complex of the catalytic portion of human hmg-CoA reductase with atorvastatin | x-ray diffraction | A, B, C, D | — | — |
| 1HWL | Complex of the catalytic portion of human hmg-CoA reductase with rosuvastatin (formally known as… | x-ray diffraction | A, B, C, D | — | — |
| 1HWL | Complex of the catalytic portion of human hmg-CoA reductase with rosuvastatin (formally known as… | x-ray diffraction | A, B, C, D | — | — |
| 2Q1L | Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2Q1L | Design and synthesis of pyrrole-based, hepatoselective hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2Q6B | Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2Q6B | Design and synthesis of novel, conformationally restricted hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2Q6C | Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2Q6C | Design and synthesis of novel, conformationally restricted hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2R4F | Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2R4F | Substituted pyrazoles as hepatselective hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3BGL | Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase… | x-ray diffraction | A, B, C, D | — | — |
| 3BGL | Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as hmg-CoA reductase… | x-ray diffraction | A, B, C, D | — | — |
| 3CCT | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CCT | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CCW | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CCW | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CCZ | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CCZ | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD0 | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD0 | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD5 | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD5 | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD7 | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CD7 | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CDA | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CDA | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CDB | Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3CDB | Thermodynamic and structure guided design of statin hmg-CoA reductase inhibitors | x-ray diffraction | A, B, C, D | — | — |
| P04035 | AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (P04035) | predicted | A | — | — |
Experiment against prediction
- 1HWI chain D against the predicted model P04035: TM-score 1.00, RMSD 0.41 Å
- 1HW8 chain C against the predicted model P04035: TM-score 1.00, RMSD 0.41 Å
- 1HW8 chain C against the predicted model P04035: TM-score 1.00, RMSD 0.41 Å
- 1HW8 chain D against the predicted model P04035: TM-score 1.00, RMSD 0.42 Å
- 1HW8 chain D against the predicted model P04035: TM-score 1.00, RMSD 0.42 Å
- 1HWI chain C against the predicted model P04035: TM-score 1.00, RMSD 0.43 Å
- 1HWK chain D against the predicted model P04035: TM-score 1.00, RMSD 0.46 Å
- 1HWL chain D against the predicted model P04035: TM-score 1.00, RMSD 0.46 Å
- 1HW9 chain D against the predicted model P04035: TM-score 1.00, RMSD 0.46 Å
- 1HWJ chain D against the predicted model P04035: TM-score 1.00, RMSD 0.50 Å
Elsewhere
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