UniProt P03960
Potassium-transporting ATPase ATP-binding subunit (P03960)
Potassium-transporting ATPase ATP-binding subunit (UniProt P03960), EC 7.2.2.6: 33 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 162 pockets. Binding sites, druggability and experiment against…
- UniProt
- P03960
- Protein
- Potassium-transporting ATPase ATP-binding subunit
- EC
- 7.2.2.6
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 162 · 15 records with a druggable one
Structures
34 records of P03960 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SVJ | The solution structure of the nucleotide binding domain of KdpB | solution nmr | A | — | — |
| 1SVJ | The solution structure of the nucleotide binding domain of kdpb | solution nmr | A | — | — |
| 1U7Q | The solution structure of the nucleotide binding domain of kdpb | solution nmr | A | — | — |
| 1U7Q | The solution structure of the nucleotide binding domain of kdpb | solution nmr | A | — | — |
| 2A00 | The solution structure of the AMP-PNP bound nucleotide binding domain of KdpB | solution nmr | A | — | — |
| 2A00 | The solution structure of the AMP-pnp bound nucleotide binding domain of kdpb | solution nmr | A | — | — |
| 2A29 | The solution structure of the AMP-PNP bound nucleotide binding domain of KdpB | solution nmr | A | — | — |
| 2A29 | The solution structure of the AMP-pnp bound nucleotide binding domain of kdpb | solution nmr | A | — | — |
| 5MRW | Structure of the KdpFABC complex | x-ray diffraction | B, F, J | PX4 | — |
| 5MRW | Structure of the kdpfabc complex | x-ray diffraction | B, F, J | PX4 | — |
| 6HRA | Cryo-EM structure of the KdpFABC complex in an E1 outward-facing state (state 1) | electron microscopy | B | — | — |
| 6HRA | Cryo-EM structure of the kdpfabc complex in an E1 outward-facing state (state 1) | electron microscopy | B | — | — |
| 6HRB | Cryo-EM structure of the KdpFABC complex in an E2 inward-facing state (state 2) | electron microscopy | B | — | — |
| 6HRB | Cryo-EM structure of the kdpfabc complex in an E2 inward-facing state (state 2) | electron microscopy | B | — | — |
| 7BGY | Cryo-EM Structure of KdpFABC in E2Pi state with MgF4 | electron microscopy | B | 9Y0, MG, MF4 | 8 (best 0.72) |
| 7BGY | Cryo-EM structure of kdpfabc in E2PI state with MGF4 | electron microscopy | B | 9Y0, MG, MF4 | — |
| 7BH1 | Cryo-EM Structure of KdpFABC in E1 state with K | electron microscopy | B | 9Y0 | 11 (best 0.72) |
| 7BH1 | Cryo-EM structure of kdpfabc in E1 state with K | electron microscopy | B | 9Y0 | — |
| 7BH2 | Cryo-EM Structure of KdpFABC in E2Pi state with BeF3 and K+ | electron microscopy | B | 9Y0, MG, BEF | 10 (best 0.73) |
| 7BH2 | Cryo-EM structure of kdpfabc in E2PI state with BEF3 and K+ | electron microscopy | B | 9Y0, MG, BEF | — |
| 7LC3 | CryoEM Structure of KdpFABC in E1-ATP state | electron microscopy | B | 9Y0, MG, ACP | 10 (best 0.80) |
| 7LC3 | Cryoem structure of kdpfabc in E1-ATP state | electron microscopy | B | 9Y0, MG, ACP | — |
| 7LC6 | Cryo-EM Structure of KdpFABC in E2-P state with BeF3 | electron microscopy | B | 9Y0, MG | 12 (best 0.81) |
| 7LC6 | Cryo-EM structure of kdpfabc in E2-P state with BEF3 | electron microscopy | B | 9Y0, MG | — |
| 7ZRD | Cryo-EM map of the WT KdpFABC complex in the E1-P tight conformation, stabilised with the inhibitor… | electron microscopy | B | K, CDL, VO4 | 10 (best 0.78) |
| 7ZRE | Cryo-EM map of the WT KdpFABC complex in the E1-P tight conformation, under turnover conditions | electron microscopy | B | CDL, K | 11 (best 0.79) |
| 7ZRG | Cryo-EM map of the WT KdpFABC complex in the E1_ATPearly conformation, under turnover conditions | electron microscopy | B | K, CDL, ATP | 13 (best 0.81) |
| 7ZRH | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | B | K, CDL | 11 (best 0.79) |
| 7ZRI | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | B | K, CDL | 13 (best 0.81) |
| 7ZRJ | Cryo-EM structure of the KdpFABC complex in a nucleotide-free E1 conformation loaded with K+ | electron microscopy | B | K, CDL | 13 (best 0.80) |
| 7ZRK | Cryo-EM map of the WT KdpFABC complex in the E1-P_ADP conformation, under turnover conditions | electron microscopy | B | K, CDL, ADP | 12 (best 0.78) |
| 7ZRL | Cryo-EM map of the unphosphorylated KdpFABC complex in the E2-P conformation, under turnover… | electron microscopy | B | — | 10 (best 0.73) |
| 7ZRM | Cryo-EM map of the unphosphorylated KdpFABC complex in the E1-P_ADP conformation, under turnover… | electron microscopy | B | K, ADP, MG | 10 (best 0.81) |
| P03960 | AlphaFold monomer V2.0 prediction for potassium-transporting ATPase ATP-binding subunit (P03960) | predicted | A | — | 8 (best 0.62) |
Ligands
- 9Y0 · (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate · in 10 records
- MG · Magnesium ion · in 9 records
- K · Potassium ion · in 8 records
- CDL · Cardiolipin · in 7 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- BEF · Beryllium trifluoride ion · in 2 records
- MF4 · Tetrafluoromagnesate(2-) · in 2 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 2 records
- ATP · Adenosine-5'-triphosphate · in 1 record
- VO4 · Vanadate ion · in 1 record
Experiment against prediction
- 2A29 chain A against the predicted model P03960: TM-score 0.93, RMSD 1.37 Å
- 2A29 chain A against the predicted model P03960: TM-score 0.93, RMSD 1.37 Å
- 2A00 chain A against the predicted model P03960: TM-score 0.93, RMSD 1.47 Å
- 2A00 chain A against the predicted model P03960: TM-score 0.93, RMSD 1.47 Å
- 1SVJ chain A against the predicted model P03960: TM-score 0.91, RMSD 1.52 Å
- 1SVJ chain A against the predicted model P03960: TM-score 0.91, RMSD 1.52 Å
- 1U7Q chain A against the predicted model P03960: TM-score 0.91, RMSD 1.54 Å
- 1U7Q chain A against the predicted model P03960: TM-score 0.91, RMSD 1.54 Å
- 6HRA chain B against the predicted model P03960: TM-score 0.90, RMSD 3.13 Å
- 6HRA chain B against the predicted model P03960: TM-score 0.90, RMSD 3.13 Å
Elsewhere
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