UniProt P01909
HLA class II histocompatibility antigen, DQ alpha 1 chain (P01909)
HLA class II histocompatibility antigen, DQ alpha 1 chain (UniProt P01909): 35 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 107 pockets. Binding sites, druggability and experiment against…
- UniProt
- P01909
- Protein
- HLA class II histocompatibility antigen, DQ alpha 1 chain
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 107 · 10 records with a druggable one
Structures
36 records of P01909 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S9V | Crystal structure of HLA-DQ2 complexed with deamidated gliadin peptide | x-ray diffraction | A, D | — | 8 (best 0.48) |
| 1S9V | Crystal structure of HLA-DQ2 complexed with deamidated gliadin peptide | x-ray diffraction | A, D | — | — |
| 4GG6 | Protein complex | x-ray diffraction | A, C | — | — |
| 4GG6 | Protein complex | x-ray diffraction | A, C | — | — |
| 4OZF | JR5.1 protein complex | x-ray diffraction | A | — | — |
| 4OZF | JR5.1 protein complex | x-ray diffraction | A | — | — |
| 4OZG | D2 protein complex | x-ray diffraction | A, C | — | — |
| 4OZG | D2 protein complex | x-ray diffraction | A, C | — | — |
| 4OZH | S16 protein complex | x-ray diffraction | A, C | — | — |
| 4OZH | S16 protein complex | x-ray diffraction | A, C | — | — |
| 4OZI | S2 protein complex | x-ray diffraction | A, C | — | — |
| 4OZI | S2 protein complex | x-ray diffraction | A, C | — | — |
| 5KSA | Bel602-DQ8.5-glia-gamma1 complex | x-ray diffraction | A | NAG, CA | — |
| 5KSA | BEL602-DQ8.5-glia-GAMMA1 complex | x-ray diffraction | A | NAG, CA | — |
| 5KSB | T15-DQ8.5-glia-gamma1 complex | x-ray diffraction | A, C | NAG | 6 (best 0.53) |
| 5KSB | T15-DQ8.5-glia-GAMMA1 complex | x-ray diffraction | A, C | NAG | — |
| 5KSU | Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution | x-ray diffraction | A, D | — | — |
| 5KSU | Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution | x-ray diffraction | A, D | — | — |
| 6MFF | HLA-DQ2-glia-omega1 | x-ray diffraction | A | NAG | 3 (best 0.48) |
| 6MFF | HLA-DQ2-glia-OMEGA1 | x-ray diffraction | A | NAG | — |
| 6MFG | HLA-DQ2-glia-alpha1 | x-ray diffraction | C, A | NAG | 7 (best 0.69) |
| 6MFG | HLA-DQ2-glia-ALPHA1 | x-ray diffraction | C, A | NAG | — |
| 6U3M | DQ2-P.fluor-alpha1a | x-ray diffraction | C, A | NAG | 5 (best 0.52) |
| 6U3M | DQ2-P.FLUOR-ALPHA1A | x-ray diffraction | C, A | NAG | — |
| 7SG0 | W316 TCR in complex with HLA-DQ2-omega1 | x-ray diffraction | A | NAG | 6 (best 0.71) |
| 7SG0 | W316 TCR in complex with HLA-DQ2-OMEGA1 | x-ray diffraction | A | NAG | — |
| 7SG1 | XPA5 TCR in complex with HLA-DQ2-alpha1 | x-ray diffraction | A, F | NAG, CA | 15 (best 0.51) |
| 7SG1 | XPA5 TCR in complex with HLA-DQ2-ALPHA1 | x-ray diffraction | A, F | NAG, CA | — |
| 7SG2 | XPA5 TCR in complex with HLA-DQ2-omega1 | x-ray diffraction | A, F | NAG | — |
| 7SG2 | XPA5 TCR in complex with HLA-DQ2-OMEGA1 | x-ray diffraction | A, F | NAG | — |
| 8VSP | Cryo-EM structure of human invariant chain in complex with HLA-DQ | electron microscopy | A, D, G | NAG | 19 (best 0.75) |
| 8W83 | HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 | x-ray diffraction | C, G, K, O | NAG | 7 (best 0.57) |
| 8W84 | HLA-DQ2.5-alpha2 gliadin peptide in complex with DQN0344AE02 | x-ray diffraction | C | NAG | 6 (best 0.68) |
| 8W85 | HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01 | x-ray diffraction | C, G | NAG | 12 (best 0.65) |
| 8W86 | HLA-DQ2.5-B/C hordein peptide in complex with DQN0385AE02 | x-ray diffraction | C, G | NAG | 13 (best 0.64) |
| P01909 | AlphaFold monomer V2.0 prediction for HLA class II histocompatibility antigen, dq alpha 1 chain… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7SG2 chain F against the predicted model P01909: TM-score 0.97, RMSD 1.12 Å
- 7SG2 chain F against the predicted model P01909: TM-score 0.97, RMSD 1.12 Å
- 8W83 chain C against the predicted model P01909: TM-score 0.96, RMSD 1.13 Å
- 8W83 chain O against the predicted model P01909: TM-score 0.96, RMSD 1.15 Å
- 1S9V chain D against the predicted model P01909: TM-score 0.96, RMSD 1.10 Å
- 1S9V chain D against the predicted model P01909: TM-score 0.96, RMSD 1.10 Å
- 8W83 chain K against the predicted model P01909: TM-score 0.96, RMSD 1.14 Å
- 1S9V chain A against the predicted model P01909: TM-score 0.96, RMSD 1.13 Å
- 1S9V chain A against the predicted model P01909: TM-score 0.96, RMSD 1.13 Å
- 7SG2 chain A against the predicted model P01909: TM-score 0.96, RMSD 1.17 Å
Elsewhere
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