UniProt P01024
Complement C3 (P01024)
Complement C3 (UniProt P01024): 117 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 313 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01024
- Protein
- Complement C3
- Experimental structures
- 117
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 313 · 22 records with a druggable one
Structures
118 records of P01024 in the MolNFT archive: 117 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C3D | X-ray crystal structure of C3D: a C3 fragment and ligand for complement receptor 2 | x-ray diffraction | A | — | — |
| 1C3D | X-ray crystal structure of C3D: a C3 fragment and ligand for complement receptor 2 | x-ray diffraction | A | — | — |
| 1GHQ | CR2-C3D complex structure | x-ray diffraction | A | — | — |
| 1GHQ | CR2-C3D complex structure | x-ray diffraction | A | — | — |
| 1W2S | Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering | solution scattering | A | — | — |
| 1W2S | Solution structure of CR2 scr 1-2 in its complex with C3D by X-ray scattering | solution scattering | A | — | — |
| 2A73 | Human Complement Component C3 | x-ray diffraction | A, B | — | — |
| 2A73 | Human complement component C3 | x-ray diffraction | A, B | — | — |
| 2A74 | Human Complement Component C3c | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2A74 | Human complement component C3C | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2GOX | Crystal structure of Efb-C / C3d Complex | x-ray diffraction | A, C | — | — |
| 2GOX | Crystal structure of efb-C / C3D complex | x-ray diffraction | A, C | — | — |
| 2I07 | Human Complement Component C3b | x-ray diffraction | A, B | — | — |
| 2I07 | Human complement component C3B | x-ray diffraction | A, B | — | — |
| 2ICE | CRIg bound to C3c | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2ICE | Crig bound to C3C | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2ICF | CRIg bound to C3b | x-ray diffraction | A, B | — | — |
| 2ICF | Crig bound to C3B | x-ray diffraction | A, B | — | — |
| 2NOJ | Crystal structure of Ehp / C3d complex | x-ray diffraction | A, C, E, G | — | — |
| 2NOJ | Crystal structure of ehp / C3D complex | x-ray diffraction | A, C, E, G | — | — |
| 2QKI | Human C3c in complex with the inhibitor compstatin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2QKI | Human C3C in complex with the inhibitor compstatin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2WII | Complement C3b in complex with factor H domains 1-4 | x-ray diffraction | A, B | — | — |
| 2WII | Complement C3B in complex with factor H domains 1-4 | x-ray diffraction | A, B | — | — |
| 2WIN | C3 convertase (C3bBb) stabilized by SCIN | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WIN | C3 convertase (C3BBB) stabilized by scin | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2WY7 | Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement fragment C3d… | x-ray diffraction | A | — | — |
| 2WY7 | Staphylococcus aureus complement subversion protein sbi-IV in complex with complement fragment C3D… | x-ray diffraction | A | — | — |
| 2WY8 | Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement fragment C3d | x-ray diffraction | A | — | — |
| 2WY8 | Staphylococcus aureus complement subversion protein sbi-IV in complex with complement fragment C3D | x-ray diffraction | A | — | — |
| 2XQW | Structure of Factor H domains 19-20 in complex with complement C3d | x-ray diffraction | A, B | — | — |
| 2XQW | Structure of factor H domains 19-20 in complex with complement C3D | x-ray diffraction | A, B | — | — |
| 2XWB | Crystal Structure of Complement C3b in complex with Factors B and D | x-ray diffraction | A, B, C, D | — | — |
| 2XWB | Crystal structure of complement C3B in complex with factors B and D | x-ray diffraction | A, B, C, D | — | — |
| 2XWJ | Crystal Structure of Complement C3b in Complex with Factor B | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2XWJ | Crystal structure of complement C3B in complex with factor B | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3D5R | Crystal Structure of Efb-C (N138A) / C3d Complex | x-ray diffraction | A, B | — | — |
| 3D5R | Crystal structure of efb-C (N138A) / C3D complex | x-ray diffraction | A, B | — | — |
| 3D5S | Crystal Structure of Efb-C (R131A) / C3d Complex | x-ray diffraction | A, B | — | — |
| 3D5S | Crystal structure of efb-C (R131A) / C3D complex | x-ray diffraction | A, B | — | — |
| 3G6J | C3b in complex with a C3b specific Fab | x-ray diffraction | A, B, C, D | — | — |
| 3G6J | C3B in complex with a C3B specific Fab | x-ray diffraction | A, B, C, D | — | — |
| 3L3O | Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3c | x-ray diffraction | A, B, F, D, C, E | — | — |
| 3L3O | Staphylococcal complement inhibitor (scin) in complex with human complement component C3C | x-ray diffraction | A, B, F, D, C, E | — | — |
| 3L5N | Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b | x-ray diffraction | A, B | — | — |
| 3L5N | Staphylococcal complement inhibitor (scin) in complex with human complement component C3B | x-ray diffraction | A, B | — | — |
| 3NMS | Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c | x-ray diffraction | A, C, B | — | — |
| 3NMS | Staphylococcal complement inhibitor (scin) in complex with human complement C3C | x-ray diffraction | A, C, B | — | — |
| 3OED | The structure of the complex between complement receptor CR2 and its ligand complement fragment C3d | x-ray diffraction | A, B | — | — |
| 3OED | The structure of the complex between complement receptor CR2 and its ligand complement fragment C3D | x-ray diffraction | A, B | — | — |
| 3OHX | Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of… | x-ray diffraction | A, B, C, E, F, D | — | — |
| 3OHX | Molecular basis for complement recognition and inhibition determined by crystallographic studies of… | x-ray diffraction | A, B, C, E, F, D | — | — |
| 3OXU | Complement components factor H CCP19-20 and C3d in complex | x-ray diffraction | A, B, C | — | — |
| 3OXU | Complement components factor H CCP19-20 and C3D in complex | x-ray diffraction | A, B, C | — | — |
| 3RJ3 | Complement components factor H CCP19-20 (S1191L mutant) and C3D in complex | x-ray diffraction | A, B, C | — | — |
| 3RJ3 | Complement components factor H CCP19-20 (S1191L mutant) and C3D in complex | x-ray diffraction | A, B, C | — | — |
| 3T4A | Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3T4A | Structure of a truncated form of staphylococcal complement inhibitor B bound to human C3C at 3.4… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4HW5 | Crystal Structure of the Human C3a anaphylatoxin | x-ray diffraction | A, B | — | — |
| 4HW5 | Crystal structure of the human C3A anaphylatoxin | x-ray diffraction | A, B | — | — |
58 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 25 records
- MG · Magnesium ion · in 8 records
- CA · Calcium ion · in 3 records
- CL · Chloride ion · in 3 records
- BMA · beta-D-mannopyranose · in 2 records
- ACM · Acetamide · in 1 record
- EXL · 1-methyl-L-tryptophan · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
- IOD · Iodide ion · in 1 record
- K · Potassium ion · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 5FO7 chain A against the predicted model P01024: TM-score 0.99, RMSD 1.03 Å
- 5FO7 chain A against the predicted model P01024: TM-score 0.99, RMSD 1.03 Å
- 2WII chain A against the predicted model P01024: TM-score 0.99, RMSD 1.03 Å
- 2WII chain A against the predicted model P01024: TM-score 0.99, RMSD 1.03 Å
- 5FOA chain A against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
- 5FOA chain A against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
- 2XWB chain C against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
- 2XWB chain C against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
- 2XWB chain A against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
- 2XWB chain A against the predicted model P01024: TM-score 0.99, RMSD 1.04 Å
Elsewhere
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