UniProt P00742
Coagulation factor X (P00742)
Coagulation factor X (UniProt P00742), EC 3.4.21.6: 309 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00742
- Protein
- Coagulation factor X
- EC
- 3.4.21.6
- Experimental structures
- 309
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 77 · 19 records with a druggable one
Structures
310 records of P00742 in the MolNFT archive: 309 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C5M | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | D, F | — | — |
| 1C5M | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | D, F | — | — |
| 1EZQ | Crystal structure of human coagulation factor xa complexed with RPR128515 | x-ray diffraction | A, B | — | — |
| 1EZQ | Crystal structure of human coagulation factor xa complexed with RPR128515 | x-ray diffraction | A, B | — | — |
| 1F0R | Crystal structure of human coagulation factor xa complexed with RPR208815 | x-ray diffraction | A, B | — | — |
| 1F0R | Crystal structure of human coagulation factor xa complexed with RPR208815 | x-ray diffraction | A, B | — | — |
| 1F0S | Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707 | x-ray diffraction | A, B | — | — |
| 1F0S | Crystal structure of human coagulation factor xa complexed with RPR208707 | x-ray diffraction | A, B | — | — |
| 1FAX | Coagulation factor xa inhibitor complex | x-ray diffraction | A, L | — | — |
| 1FAX | Coagulation factor xa inhibitor complex | x-ray diffraction | A, L | — | — |
| 1FJS | Crystal structure of the inhibitor zk-807834 (ci-1031) complexed with factor xa | x-ray diffraction | A, L | — | — |
| 1FJS | Crystal structure of the inhibitor zk-807834 (ci-1031) complexed with factor xa | x-ray diffraction | A, L | — | — |
| 1G2L | Factor xa inhibitor complex | x-ray diffraction | A, B | — | — |
| 1G2L | Factor xa inhibitor complex | x-ray diffraction | A, B | — | — |
| 1G2M | Factor xa inhibitor complex | x-ray diffraction | A, B | — | — |
| 1G2M | Factor xa inhibitor complex | x-ray diffraction | A, B | — | — |
| 1HCG | Structure of human DES(1-45) factor xa at 2.2 ångströms resolution | x-ray diffraction | A, B | — | — |
| 1HCG | Structure of human DES(1-45) factor xa at 2.2 ångströms resolution | x-ray diffraction | A, B | — | — |
| 1IOE | Human coagulation factor Xa in complex with M55532 | x-ray diffraction | A, L | — | — |
| 1IOE | Human coagulation factor xa in complex with M55532 | x-ray diffraction | A, L | — | — |
| 1IQE | Human coagulation factor Xa in complex with M55590 | x-ray diffraction | A, L | — | — |
| 1IQE | Human coagulation factor xa in complex with M55590 | x-ray diffraction | A, L | — | — |
| 1IQF | Human coagulation factor Xa in complex with M55165 | x-ray diffraction | A, L | — | — |
| 1IQF | Human coagulation factor xa in complex with M55165 | x-ray diffraction | A, L | — | — |
| 1IQG | Human coagulation factor Xa in complex with M55159 | x-ray diffraction | A, L | — | — |
| 1IQG | Human coagulation factor xa in complex with M55159 | x-ray diffraction | A, L | — | — |
| 1IQH | Human coagulation factor Xa in complex with M55143 | x-ray diffraction | A, L | — | — |
| 1IQH | Human coagulation factor xa in complex with M55143 | x-ray diffraction | A, L | — | — |
| 1IQI | Human coagulation factor Xa in complex with M55125 | x-ray diffraction | A, L | — | — |
| 1IQI | Human coagulation factor xa in complex with M55125 | x-ray diffraction | A, L | — | — |
| 1IQJ | Human coagulation factor Xa in complex with M55124 | x-ray diffraction | A, L | — | — |
| 1IQJ | Human coagulation factor xa in complex with M55124 | x-ray diffraction | A, L | — | — |
| 1IQK | Human coagulation factor Xa in complex with M55113 | x-ray diffraction | A, L | — | — |
| 1IQK | Human coagulation factor xa in complex with M55113 | x-ray diffraction | A, L | — | — |
| 1IQL | Human coagulation factor Xa in complex with M54476 | x-ray diffraction | A, L | — | — |
| 1IQL | Human coagulation factor xa in complex with M54476 | x-ray diffraction | A, L | — | — |
| 1IQM | Human coagulation factor Xa in complex with M54471 | x-ray diffraction | A, L | — | — |
| 1IQM | Human coagulation factor xa in complex with M54471 | x-ray diffraction | A, L | — | — |
| 1IQN | Human coagulation factor Xa in complex with M55192 | x-ray diffraction | A, L | — | — |
| 1IQN | Human coagulation factor xa in complex with M55192 | x-ray diffraction | A, L | — | — |
| 1KSN | Crystal Structure of Human Coagulation Factor XA Complexed with FXV673 | x-ray diffraction | A, B | — | — |
| 1KSN | Crystal structure of human coagulation factor xa complexed with FXV673 | x-ray diffraction | A, B | — | — |
| 1LPG | Crystal structure of fxa in complex with 79. | x-ray diffraction | A, B | — | — |
| 1LPG | Crystal structure of fxa in complex with 79. | x-ray diffraction | A, B | — | — |
| 1LPK | Crystal structure of fxa in complex with 125. | x-ray diffraction | A, B | — | — |
| 1LPK | Crystal structure of fxa in complex with 125. | x-ray diffraction | A, B | — | — |
| 1LPZ | Crystal structure of fxa in complex with 41. | x-ray diffraction | A, B | — | — |
| 1LPZ | Crystal structure of fxa in complex with 41. | x-ray diffraction | A, B | — | — |
| 1LQD | Crystal structure of fxa in complex with 45. | x-ray diffraction | A, B | — | — |
| 1LQD | Crystal structure of fxa in complex with 45. | x-ray diffraction | A, B | — | — |
| 1MQ5 | Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1… | x-ray diffraction | A, L | — | — |
| 1MQ5 | Crystal structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)… | x-ray diffraction | A, L | — | — |
| 1MQ6 | Crystal Structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]-6-methoxyphenyl]… | x-ray diffraction | A, L | — | — |
| 1MQ6 | Crystal structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)… | x-ray diffraction | A, L | — | — |
| 1NFU | Crystal structure of human coagulation factor xa complexed with RPR132747 | x-ray diffraction | A, B | — | — |
| 1NFU | Crystal structure of human coagulation factor xa complexed with RPR132747 | x-ray diffraction | A, B | — | — |
| 1NFW | Crystal structure of human coagulation factor xa complexed with RPR209685 | x-ray diffraction | A, B | — | — |
| 1NFW | Crystal structure of human coagulation factor xa complexed with RPR209685 | x-ray diffraction | A, B | — | — |
| 1NFX | Crystal structure of human coagulation factor xa complexed with RPR208944 | x-ray diffraction | A, B | — | — |
| 1NFX | Crystal structure of human coagulation factor xa complexed with RPR208944 | x-ray diffraction | A, B | — | — |
250 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 20 records
- CA · Calcium ion · in 7 records
- AKG · 2-oxoglutaric acid · in 4 records
- NA · Sodium ion · in 3 records
- Q1Z · (3~{R})-3-methyl-2-oxidanylidene-pentanedioic acid · in 3 records
- PD2 · Pyridine-2,4-dicarboxylic acid · in 2 records
- RIV · 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide · in 2 records
- U4Q · 5-fluoranylpyridine-2,4-dicarboxylic acid · in 2 records
- 0GJ · L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide · in 1 record
- 6PK · O-benzyl-N-(benzylsulfonyl)-D-seryl-N-[(4-carbamimidoylphenyl)methyl]glycinamide · in 1 record
- IO9 · (2~{R})-2-oxidanyl-4-oxidanylidene-pentanedioic acid · in 1 record
- IOW · (2~{S})-2-methyl-2-oxidanyl-4-oxidanylidene-pentanedioic acid · in 1 record
- Q1W · 2,2-dimethyl-4-oxidanylidene-pentanedioic acid · in 1 record
- S2G · (2S)-2-hydroxypentanedioic acid · in 1 record
- UQK · N-oxalyl-alpha-methylalanine · in 1 record
- YQX · 2-oxidanylideneoctanedioic acid · in 1 record
Experiment against prediction
- 3Q3K chain A against the predicted model P00742: TM-score 0.99, RMSD 0.82 Å
- 3Q3K chain A against the predicted model P00742: TM-score 0.99, RMSD 0.82 Å
- 2EI7 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.82 Å
- 2EI7 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.82 Å
- 2EI6 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.83 Å
- 2EI6 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.83 Å
- 2D1J chain A against the predicted model P00742: TM-score 0.99, RMSD 0.83 Å
- 2D1J chain A against the predicted model P00742: TM-score 0.99, RMSD 0.83 Å
- 1WU1 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.84 Å
- 1WU1 chain A against the predicted model P00742: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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