UniProt P00730
Carboxypeptidase a (P00730)
Carboxypeptidase a (UniProt P00730), EC 3.4.17.1: 58 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00730
- Protein
- Carboxypeptidase a
- EC
- 3.4.17.1
- Experimental structures
- 58
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 2 · 1 record with a druggable one
Structures
59 records of P00730 in the MolNFT archive: 58 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ARL | Carboxypeptidase a with zn removed | x-ray diffraction | A | — | — |
| 1ARL | Carboxypeptidase a with zn removed | x-ray diffraction | A | — | — |
| 1ARM | Carboxypeptidase a with zn replaced by hg | x-ray diffraction | A | — | — |
| 1ARM | Carboxypeptidase a with zn replaced by hg | x-ray diffraction | A | — | — |
| 1BAV | Carboxypeptidase a complexed with 2-benzyl-3-iodo-propanoic acid (bip) | x-ray diffraction | A, B, C, D | — | — |
| 1BAV | Carboxypeptidase a complexed with 2-benzyl-3-iodo-propanoic acid (bip) | x-ray diffraction | A, B, C, D | — | — |
| 1CBX | Crystal structure of the complex between carboxypeptidase a and the biproduct analog inhibitor… | x-ray diffraction | A | — | — |
| 1CBX | Crystal structure of the complex between carboxypeptidase a and the biproduct analog inhibitor… | x-ray diffraction | A | — | — |
| 1CPS | Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc… | x-ray diffraction | A | — | — |
| 1CPS | Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc… | x-ray diffraction | A | — | — |
| 1CPX | Beta form of carboxypeptidase a (residues 3-307) from bovine pancreas in an orthorhombic crystal… | x-ray diffraction | A | — | — |
| 1CPX | Beta form of carboxypeptidase a (residues 3-307) from bovine pancreas in an orthorhombic crystal… | x-ray diffraction | A | — | — |
| 1EE3 | Cadmium-substituted bovine pancreatic carboxypeptidase A (alfa-form) at pH 7.5 and 2 mM chloride in… | x-ray diffraction | P | — | — |
| 1EE3 | Cadmium-substituted bovine pancreatic carboxypeptidase a (alfa-form) at pH 7.5 and 2 mm chloride in… | x-ray diffraction | P | — | — |
| 1ELL | Cadmium-substituted bovine pancreatic carboxypeptidase a (alfa-form) at pH 7.5 and 0.25 M chloride… | x-ray diffraction | P | — | — |
| 1ELL | Cadmium-substituted bovine pancreatic carboxypeptidase a (alfa-form) at pH 7.5 and 0.25 M chloride… | x-ray diffraction | P | — | — |
| 1ELM | Cadmium-substituted bovine pacreatic carboxypeptidase a (alfa-form) at pH 5.5 and 2 mm chloride in… | x-ray diffraction | P | — | — |
| 1ELM | Cadmium-substituted bovine pacreatic carboxypeptidase a (alfa-form) at pH 5.5 and 2 mm chloride in… | x-ray diffraction | P | — | — |
| 1F57 | Carboxypeptidase a complex with D-cysteine at 1.75 a | x-ray diffraction | A | — | — |
| 1F57 | Carboxypeptidase a complex with D-cysteine at 1.75 a | x-ray diffraction | A | — | — |
| 1HDQ | Crystal structure of bovine pancreatic carboxypeptidase A complexed with D-N-hydroxyaminocarbonyl… | x-ray diffraction | A | — | — |
| 1HDQ | Crystal structure of bovine pancreatic carboxypeptidase a complexed with D-N-hydroxyaminocarbonyl… | x-ray diffraction | A | — | — |
| 1HDU | Crystal structure of bovine pancreatic carboxypeptidase A complexed with aminocarbonylphenylalanine… | x-ray diffraction | A, B, D, E | — | — |
| 1HDU | Crystal structure of bovine pancreatic carboxypeptidase a complexed with aminocarbonylphenylalanine… | x-ray diffraction | A, B, D, E | — | — |
| 1HEE | Crystal structure of bovine pancreatic carboxypeptidase A complexed with L-N-hydroxyaminocarbonyl… | x-ray diffraction | A, B, D, E | — | — |
| 1HEE | Crystal structure of bovine pancreatic carboxypeptidase a complexed with L-N-hydroxyaminocarbonyl… | x-ray diffraction | A, B, D, E | — | — |
| 1IY7 | Crystal Structure of CPA and sulfamide-based inhibitor complex | x-ray diffraction | A | — | — |
| 1IY7 | Crystal structure of cpa and sulfamide-based inhibitor complex | x-ray diffraction | A | — | — |
| 1M4L | Structure of native carboxypeptidase a at 1.25 resolution | x-ray diffraction | A | — | — |
| 1M4L | Structure of native carboxypeptidase a at 1.25 resolution | x-ray diffraction | A | — | — |
| 1PYT | Ternary complex of procarboxypeptidase a, proproteinase E, and chymotrypsinogen C | x-ray diffraction | A, B | — | — |
| 1PYT | Ternary complex of procarboxypeptidase a, proproteinase E, and chymotrypsinogen C | x-ray diffraction | A, B | — | — |
| 1YME | Structure of carboxypeptidase | x-ray diffraction | A | — | — |
| 1YME | Structure of carboxypeptidase | x-ray diffraction | A | — | — |
| 1ZLH | Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A | x-ray diffraction | A | — | — |
| 1ZLH | Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase a | x-ray diffraction | A | — | — |
| 2ABZ | Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine… | x-ray diffraction | A, B | — | — |
| 2ABZ | Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine… | x-ray diffraction | A, B | — | — |
| 2CTB | The high resolution crystal structure of the complex between carboxypeptidase a and L-phenyl lactate | x-ray diffraction | A | — | — |
| 2CTB | The high resolution crystal structure of the complex between carboxypeptidase a and L-phenyl lactate | x-ray diffraction | A | — | — |
| 2CTC | The high resolution crystal structure of the complex between carboxypeptidase a and L-phenyl lactate | x-ray diffraction | A | — | — |
| 2CTC | The high resolution crystal structure of the complex between carboxypeptidase a and L-phenyl lactate | x-ray diffraction | A | — | — |
| 3CPA | X-ray crystallographic investigation of substrate binding to carboxypeptidase a at subzero… | x-ray diffraction | A | — | — |
| 3CPA | X-ray crystallographic investigation of substrate binding to carboxypeptidase a at subzero… | x-ray diffraction | A | — | — |
| 3FVL | Crystallogic studies on the Complex of Carboxypeptidase A with inhibitors using alpha-hydroxy… | x-ray diffraction | A, C, E | — | — |
| 3FVL | Crystallogic studies on the complex of carboxypeptidase a with inhibitors using alpha-hydroxy… | x-ray diffraction | A, C, E | — | — |
| 3FX6 | X-RAY crystallographic studies on the complex of carboxypeptidase A with the inhibitor using… | x-ray diffraction | A, C, E | — | — |
| 3FX6 | X-ray crystallographic studies on the complex of carboxypeptidase a with the inhibitor using… | x-ray diffraction | A, C, E | — | — |
| 3KGQ | Carboxypeptidase A liganded to an organic small-molecule: conformational changes | x-ray diffraction | A | — | — |
| 3KGQ | Carboxypeptidase a liganded to an organic small-molecule: conformational changes | x-ray diffraction | A | — | — |
| 4CPA | Refined crystal structure of the potato inhibitor complex of carboxypeptidase a at 2.5 ångströms… | x-ray diffraction | A, B | — | — |
| 4CPA | Refined crystal structure of the potato inhibitor complex of carboxypeptidase a at 2.5 ångströms… | x-ray diffraction | A, B | — | — |
| 5CPA | Refined crystal structure of carboxypeptidase a at 1.54 ångströms resolution. | x-ray diffraction | A | ZN | — |
| 5CPA | Refined crystal structure of carboxypeptidase a at 1.54 ångströms resolution. | x-ray diffraction | A | — | — |
| 6CPA | Crystal structure of the complex of carboxypeptidase a with a strongly bound phosphonate in a new… | x-ray diffraction | A | ZN, ZAF | 2 (best 0.58) |
| 6CPA | Crystal structure of the complex of carboxypeptidase a with a strongly bound phosphonate in a new… | x-ray diffraction | A | ZN, ZAF | — |
| 7CPA | Comparison of the structures of three carboxypeptidase a- phosphonate complexes determined by X-ray… | — | — | — | |
| 8CPA | Comparison of the structures of three carboxypeptidase a- phosphonate complexes determined by X-ray… | x-ray diffraction | A | ZN, AGF | — |
| P00730 | AlphaFold monomer V2.0 prediction for carboxypeptidase A1 (P00730) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3KGQ chain A against the predicted model P00730: TM-score 1.00, RMSD 0.35 Å
- 3KGQ chain A against the predicted model P00730: TM-score 1.00, RMSD 0.35 Å
- 8CPA chain A against the predicted model P00730: TM-score 1.00, RMSD 0.36 Å
- 2CTC chain A against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 2CTC chain A against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 6CPA chain A against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 6CPA chain A against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 3FX6 chain E against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 3FX6 chain E against the predicted model P00730: TM-score 1.00, RMSD 0.38 Å
- 3FX6 chain C against the predicted model P00730: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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