UniProt P00492
Hypoxanthine-guanine phosphoribosyltransferase (P00492)
Hypoxanthine-guanine phosphoribosyltransferase (UniProt P00492), EC 2.4.2.8: 44 experimental structures on GenesisL1, 7 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00492
- Protein
- Hypoxanthine-guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 40 · 4 records with a druggable one
Structures
44 records of P00492 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BZY | Human hgprtase with transition state inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1BZY | Human hgprtase with transition state inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1D6N | Ternary complex structure of human hgprtase, prpp, MG2+, and the inhibitor hpp reveals the… | x-ray diffraction | A, B | — | — |
| 1D6N | Ternary complex structure of human hgprtase, prpp, MG2+, and the inhibitor hpp reveals the… | x-ray diffraction | A, B | — | — |
| 1HMP | The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound gmp | x-ray diffraction | A, B | — | — |
| 1HMP | The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound gmp | x-ray diffraction | A, B | — | — |
| 1Z7G | Free human HGPRT | x-ray diffraction | A, B, C, D | — | — |
| 1Z7G | Free human hgprt | x-ray diffraction | A, B, C, D | — | — |
| 2VFA | Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine… | x-ray diffraction | A, B | — | — |
| 2VFA | Crystal structure of a chimera of plasmodium falciparum and human hypoxanthine-guanine… | x-ray diffraction | A, B | — | — |
| 3GEP | Human hypoxanthine guanine phosphoribosyltranserfase in complex with… | x-ray diffraction | A, B | — | — |
| 3GEP | Human hypoxanthine guanine phosphoribosyltranserfase in complex with… | x-ray diffraction | A, B | — | — |
| 3GGC | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | — | — |
| 3GGC | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | — | — |
| 3GGJ | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | — | — |
| 3GGJ | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | — | — |
| 4IJQ | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 4IJQ | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 4KN6 | Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A | — | — |
| 4KN6 | Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A | — | — |
| 4RAB | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAB | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAC | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAC | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAD | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4RAD | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4RAN | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAN | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAO | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAO | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAQ | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 4RAQ | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the… | x-ray diffraction | A, B, C, D | — | — |
| 5BRN | Human hgprt in complex with (S)-hpephx, an acyclic nucleoside phosphonate | x-ray diffraction | A, B, C, D | — | — |
| 5BSK | Human hgprt in complex with (S)-hpepg, an acyclic nucleoside phosphonate | x-ray diffraction | A, B, C, D | — | — |
| 5HIA | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | YPG, MG | — |
| 5HIA | Human hypoxanthine-guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 5W8V | HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosp… | x-ray diffraction | A, B, C, D | 9YP, MG | 7 (best 0.83) |
| 5W8V | Human hgprt in complex with [(2-[(guanin-9-YL)METHYL]PROPANE-1,3… | x-ray diffraction | A, B, C, D | 9YP, MG | — |
| 6BNJ | Human hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | WPG, MG | 10 (best 0.84) |
| 6BNJ | Human hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | WPG, MG | — |
| 7SAN | Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with… | x-ray diffraction | A, B, C, D | 8QI | — |
| 8TPV | Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with… | x-ray diffraction | A, B, C, D | JEI, MG | 10 (best 0.83) |
| 8TPY | Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]… | x-ray diffraction | A, B, C, D | JG6, MG | 13 (best 0.78) |
| P00492 | AlphaFold monomer V2.0 prediction for hypoxanthine-guanine phosphoribosyltransferase (P00492) | — | — | — |
Ligands
- MG · Magnesium ion · in 7 records
- 9YP · {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid · in 2 records
- WPG · (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid · in 2 records
- 8QI · ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl) phosphonic acid · in 1 record
- JEI · (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid · in 1 record
- JG6 · {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid · in 1 record
- YPG · [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-yl]-3-oxidanylidene-propyl]phosphonic acid · in 1 record
Experiment against prediction
- 2VFA chain A against the predicted model P20035: TM-score 0.89, RMSD 1.92 Å
- 2VFA chain A against the predicted model P20035: TM-score 0.89, RMSD 1.92 Å
- 2VFA chain B against the predicted model P20035: TM-score 0.88, RMSD 2.09 Å
- 2VFA chain B against the predicted model P20035: TM-score 0.88, RMSD 2.09 Å
Elsewhere
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