UniProt P00338
L-lactate dehydrogenase A chain (P00338)
L-lactate dehydrogenase A chain (UniProt P00338), EC 1.1.1.27: 71 experimental structures on GenesisL1, 30 ligands bound, 187 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00338
- Protein
- L-lactate dehydrogenase A chain
- EC
- 1.1.1.27
- Experimental structures
- 71
- Predicted models
- 0
- Ligands
- 30
- Pockets
- 187 · 10 records with a druggable one
Structures
71 records of P00338 in the MolNFT archive: 71 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1I10 | Human muscle L-lactate dehydrogenase M chain, ternary complex with NADH and oxamate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1I10 | Human muscle L-lactate dehydrogenase M chain, ternary complex with NADH and oxamate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4AJP | Human LDHA in complex with 2-((4-(4-((3-((2-methyl-1,3-benzothiazol… | x-ray diffraction | A, B, C, D | — | — |
| 4AJP | Human ldha in complex with 2-((4-(4-((3-((2-methyl-1,3… | x-ray diffraction | A, B, C, D | — | — |
| 4JNK | Lactate Dehydrogenase A in complex with inhibitor compound 22 | x-ray diffraction | A, B, C, D | — | — |
| 4JNK | Lactate dehydrogenase a in complex with inhibitor compound 22 | x-ray diffraction | A, B, C, D | — | — |
| 4L4R | Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme | x-ray diffraction | A, H | — | — |
| 4L4R | Structural characterisation of the apo-form of human lactate dehydrogenase M isozyme | x-ray diffraction | A, H | — | — |
| 4L4S | Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme | x-ray diffraction | H, A | — | — |
| 4L4S | Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme | x-ray diffraction | H, A | — | — |
| 4M49 | Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18 | x-ray diffraction | A, B, C, D | — | — |
| 4M49 | Lactate dehydrogenase a in complex with a substituted pyrazine inhibitor compound 18 | x-ray diffraction | A, B, C, D | — | — |
| 4OJN | Crystal structure of human muscle L-lactate dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4OJN | Crystal structure of human muscle L-lactate dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4OKN | Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4OKN | Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4QO7 | Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-e compound 7 | x-ray diffraction | A, B, C, D | — | — |
| 4QO7 | Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound 7 | x-ray diffraction | A, B, C, D | — | — |
| 4QO8 | Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-e compound 104 | x-ray diffraction | A, B, C, D | — | — |
| 4QO8 | Lactate dehydrogenase a in complex with substituted 3-hydroxy-2- mercaptocyclohex-2-enone compound… | x-ray diffraction | A, B, C, D | — | — |
| 4QSM | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4QSM | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4QT0 | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4QT0 | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4R68 | Lactate Dehydrogenase in complex with inhibitor compound 31 | x-ray diffraction | A, B, C, D | — | — |
| 4R68 | Lactate dehydrogenase in complex with inhibitor compound 31 | x-ray diffraction | A, B, C, D | — | — |
| 4R69 | Lactate Dehydrogenase in complex with inhibitor compound 13 | x-ray diffraction | A, B, C, D | — | — |
| 4R69 | Lactate dehydrogenase in complex with inhibitor compound 13 | x-ray diffraction | A, B, C, D | — | — |
| 4RLS | Lactate Dehydrogenase in complex with inhibitor compound 47 | x-ray diffraction | A, B, C, D | — | — |
| 4RLS | Lactate dehydrogenase in complex with inhibitor compound 47 | x-ray diffraction | A, B, C, D | — | — |
| 4ZVV | Lactate dehydrogenase a in complex with a trisubstituted piperidine-2, 4-dione inhibitor gne-140 | x-ray diffraction | A, B, C, D | — | — |
| 5IXS | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9… | x-ray diffraction | A, B, C, D | TXD, 6EY, SO4, NAI | 18 (best 0.89) |
| 5IXS | Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 9… | x-ray diffraction | A, B, C, D | — | — |
| 5IXY | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31… | x-ray diffraction | A, B, C, D | NAD, SO4, GN2 | — |
| 5IXY | Lactate dehydrogenase in complex with hydroxylactam inhibitor compound 31… | x-ray diffraction | A, B, C, D | — | — |
| 5W8H | Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 11 | x-ray diffraction | A, B, C, D | 9Y1 | — |
| 5W8I | Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 23 and zinc | x-ray diffraction | A, B, C, D | ZN, 9YD | — |
| 5W8J | Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 | x-ray diffraction | A, B, C, D | 9Y7 | 20 (best 0.89) |
| 5W8J | Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 29 | x-ray diffraction | A, B, C, D | 9Y7 | — |
| 5W8K | Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH | x-ray diffraction | A, B, C, D | 9Y7, NAI | 20 (best 0.87) |
| 5W8K | Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 29 and NADH | x-ray diffraction | A, B, C, D | 9Y7, NAI | — |
| 5W8L | Crystal structure of lactate dehydrogenase a in complex with inhibitor compound 59 and NADH | x-ray diffraction | A, B, C, D | NAI, 9YA | — |
| 5ZJD | Lactate dehydrogenase with NADH and mla | x-ray diffraction | A, B, C, D, E, F, G, H | NAI | — |
| 5ZJE | LDHA-mla | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.89) |
| 5ZJE | LDHA-MLA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5ZJF | LDHA-MA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | 9G9 | — |
| 5ZJF | LDHA-MA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | 9G9 | — |
| 6BAD | Lactate Dehydrogenase in complex with inhibitor (R)-3-((2-chlorophenyl)thio)-6-(3-((4-fluorophenyl)a… | x-ray diffraction | A, B, C, D | NAD, SO4, D0Y | 20 (best 0.89) |
| 6BAD | Lactate dehydrogenase in complex with inhibitor (R)-3-((2… | x-ray diffraction | A, B, C, D | NAD, SO4, D0Y | — |
| 6BAG | Lactate dehydrogenase in complex with inhibitor (R)-5-((2… | x-ray diffraction | A, B, C, D | NAD, SO4, D0V | — |
| 6BAX | Lactate dehydrogenase in complex with inhibitor 6-(3-aminophenyl)-3… | x-ray diffraction | A, B, C, D | NAD, SO4, D4S | — |
| 6BAZ | Lactate dehydrogenase in complex with inhibitor (S)-5-((2… | x-ray diffraction | A, B, C, D | NAD, LAC, SO4, D47 | — |
| 6BB0 | Lactate dehydrogenase in complex with inhibitor (R)-3-((2… | x-ray diffraction | A, B, C, D | NAD, SO4, D3S, LAC | — |
| 6BB1 | Lactate dehydrogenase in complex with inhibitor (R)-5-((2… | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, SO4, D3J, LAC | — |
| 6BB2 | Lactate dehydrogenase in complex with inhibitor (S)-5-((2… | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, SO4, LAC, D4J | — |
| 6BB3 | Lactate dehydrogenase in complex with inhibitor 3-((2-chlorophenyl)… | x-ray diffraction | A, B, C, D | NAD, SO4, D4A | — |
| 6MV8 | Ldha structure in complex with inhibitor 14 | x-ray diffraction | A, B, C, D | NAI, SO4, D3S, LAC | — |
| 6MVA | LDHA structure in complex with inhibitor 14 | x-ray diffraction | A, B, C, D | NAI, SO4, D4S | — |
| 6MVA | Ldha structure in complex with inhibitor 14 | x-ray diffraction | A, B, C, D | NAI, SO4, D4S | — |
| 6Q0D | Crystal structure of ldha in complex with compound NCGC00384414-01 at 2.05 a resolution | x-ray diffraction | A, B, C, D, E, F | PO4, P8M, NAI | — |
11 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 16 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 15 records
- NAD · Nicotinamide-adenine-dinucleotide · in 10 records
- LAC · Lactic acid · in 5 records
- 9Y7 · 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid · in 4 records
- D4S · (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one · in 3 records
- 9G9 · 5,5'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]bis(2H-1,3-benzodioxole) · in 2 records
- D0Y · (6R)-3-[(2-chlorophenyl)sulfanyl]-6-{3-[(4-fluorophenyl)amino]phenyl}-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one · in 2 records
- D3S · (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one · in 2 records
- L5K · ~{N}-[3-[(7-nitrodibenzofuran-2-yl) sulfonylamino]phenyl]-1-oxidanyl-cyclopropane-1-carboxamide · in 2 records
- L5N · 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid · in 2 records
- P8V · 2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-{3-[(5-methylthiophen-2-yl) ethynyl]phenyl}-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid · in 2 records
- YOJ · 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl) methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid · in 2 records
- 6EY · (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one · in 1 record
- 9Y1 · 2-[3-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid · in 1 record
- 9YA · 2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid · in 1 record
- 9YD · 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1, 3-thiazole-4-carboxylic acid · in 1 record
- A1AQ0 · (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid · in 1 record
- A1AR0 · (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid · in 1 record
- CL · Chloride ion · in 1 record
- D0V · (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl) amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one · in 1 record
- D3J · (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one · in 1 record
- D47 · (3S,6S)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-6-(thiophen-3-yl) piperidine-2,4-dione · in 1 record
- D4A · (6R)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one · in 1 record
- D4J · (2S)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one · in 1 record
- GN2 · (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one · in 1 record
- P8M · 2-{3-[3-(cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl) methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
- TXD · 1,4,5,6-tetrahydronicotinamide adenine dinucleotide · in 1 record
- ZN · Zinc ion · in 1 record
Elsewhere
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