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Ligand · ZHK

ZHK · (2R)-2-{[5-cyano-4-(3,4-dichlorophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide

ZHK, (2R)-2-{[5-cyano-4-(3,4-dichlorophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide (C20 H15 Cl2 N5 O4 S2, 524.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
ZHK
Formula
C20 H15 Cl2 N5 O4 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

ZHK in 2 structures; the first of them:

  • 4JNK · Lactate Dehydrogenase A in complex with inhibitor compound 22 · ZHK A803 · binds ALA97, ARG98, SER104, ARG105, LEU108, VAL109, ASN137, PRO138 and 11 more
  • 4JNK · Lactate dehydrogenase a in complex with inhibitor compound 22 · ZHK A803 · binds ALA97, ARG98, SER104, ARG105, LEU108, VAL109, ASN137, PRO138 and 11 more

Residues it binds most

ALA 6, ASP 6, ILE 6, LEU 6, ARG 6, VAL 6, ASN 6, GLU 6, GLY 6, HIS 6 (residue and the binding sites it lines).

Found with

  • LAC · Lactic acid
  • NAI · 1,4-dihydronicotinamide adenine dinucleotide
  • SO4 · Sulfate ion
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid

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