UniProt P00178
P00178
P00178 (UniProt P00178): 39 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00178
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 2
Structures
40 records of P00178 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PO5 | Structure of mammalian cytochrome P450 2B4 | x-ray diffraction | A | — | — |
| 1PO5 | Structure of mammalian cytochrome P450 2B4 | x-ray diffraction | A | — | — |
| 1SUO | Structure of mammalian cytochrome P450 2B4 with bound 4-(4-chlorophenyl)imidazole | x-ray diffraction | A | — | — |
| 1SUO | Structure of mammalian cytochrome P450 2B4 with bound 4-(4- CHLOROPHENYL)IMIDAZOLE | x-ray diffraction | A | — | — |
| 2BDM | Structure of Cytochrome P450 2B4 with Bound Bifonazole | x-ray diffraction | A | — | — |
| 2BDM | Structure of cytochrome P450 2B4 with bound bifonazole | x-ray diffraction | A | — | — |
| 2Q6N | Structure of Cytochrome P450 2B4 with Bound 1-(4-cholorophenyl)imidazole | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 2Q6N | Structure of cytochrome P450 2B4 with bound 1-(4-cholorophenyl) imidazole | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3G5N | Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 3G5N | Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 3G93 | Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 3G93 | Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 3KW4 | Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine | x-ray diffraction | A | — | — |
| 3KW4 | Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine | x-ray diffraction | A | — | — |
| 3ME6 | Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel | x-ray diffraction | A, B, C, D | — | — |
| 3ME6 | Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel | x-ray diffraction | A, B, C, D | — | — |
| 3MVR | Crystal Structure of cytochrome P450 2B4-H226Y in a closed conformation | x-ray diffraction | A, B | — | — |
| 3MVR | Crystal structure of cytochrome P450 2B4-H226Y in a closed conformation | x-ray diffraction | A, B | — | — |
| 3R1A | Closed crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3R1A | Closed crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3R1B | Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator… | x-ray diffraction | A, B, C, D | — | — |
| 3R1B | Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator… | x-ray diffraction | A, B, C, D | — | — |
| 3TK3 | Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole | x-ray diffraction | A, B, C, D | — | — |
| 3TK3 | Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl) imidazole | x-ray diffraction | A, B, C, D | — | — |
| 3TMZ | Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine | x-ray diffraction | A | — | — |
| 3TMZ | Crystal structure of P450 2B4(H226Y) in complex with amlodipine | x-ray diffraction | A | — | — |
| 3UAS | Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene | x-ray diffraction | A | — | — |
| 3UAS | Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene | x-ray diffraction | A | — | — |
| 4H1N | Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel | x-ray diffraction | A | — | — |
| 4H1N | Crystal structure of P450 2B4 F297A mutant in complex with anti- platelet drug clopidogrel | x-ray diffraction | A | — | — |
| 4JLT | Crystal structure of P450 2B4(H226Y) in complex with paroxetine | x-ray diffraction | A | — | — |
| 4JLT | Crystal structure of P450 2B4(H226Y) in complex with paroxetine | x-ray diffraction | A | — | — |
| 4MGJ | Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI | x-ray diffraction | A | — | — |
| 4MGJ | Crystal structure of cytochrome P450 2B4 F429H in complex with 4-cpi | x-ray diffraction | A | — | — |
| 5EM4 | Structure of CYP2B4 F244W in a ligand free conformation | x-ray diffraction | A, B | HEM, CM5 | — |
| 5EM4 | Structure of CYP2B4 F244W in a ligand free conformation | x-ray diffraction | A, B | — | — |
| 5IUT | Structure of P450 2B4 F202W mutant | x-ray diffraction | A | — | — |
| 5IUZ | Structure of P450 2B4 F202W mutant (cymal-5) | x-ray diffraction | A, B | — | — |
| 6BWW | Crystal structure of an acetate and cymal-5 bound cytochrome P450 2B4 F429H mutant | x-ray diffraction | A | HEM, CM5 | — |
| P00178 | AlphaFold monomer V2.0 prediction for cytochrome P450 2B4 (P00178) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4MGJ chain A against the predicted model P00178: TM-score 0.99, RMSD 0.79 Å
- 4MGJ chain A against the predicted model P00178: TM-score 0.99, RMSD 0.79 Å
- 3R1A chain H against the predicted model P00178: TM-score 0.99, RMSD 1.06 Å
- 3R1A chain H against the predicted model P00178: TM-score 0.99, RMSD 1.06 Å
- 3UAS chain A against the predicted model P00178: TM-score 0.99, RMSD 0.78 Å
- 3UAS chain A against the predicted model P00178: TM-score 0.99, RMSD 0.78 Å
- 3R1A chain A against the predicted model P00178: TM-score 0.99, RMSD 0.99 Å
- 3R1A chain A against the predicted model P00178: TM-score 0.99, RMSD 0.99 Å
- 3R1A chain D against the predicted model P00178: TM-score 0.99, RMSD 1.02 Å
- 3R1A chain D against the predicted model P00178: TM-score 0.99, RMSD 1.02 Å
Elsewhere
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