UniProt O95631
Netrin-1 (O95631)
Netrin-1 (UniProt O95631): 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95631
- Protein
- Netrin-1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 42 · 3 records with a druggable one
Structures
11 records of O95631 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4URT | The crystal structure of a fragment of netrin-1 in complex with FN5- FN6 of DCC | x-ray diffraction | A | NAG, CA, CL, SO4 | 8 (best 0.50) |
| 4URT | The crystal structure of a fragment of netrin-1 in complex with FN5- FN6 of dcc | x-ray diffraction | A | — | — |
| 6FKQ | The crystal structure of a fragment of netrin-1 in complex with a fragment of draxin | x-ray diffraction | A | NAG, CA, SO4 | 3 (best 0.45) |
| 6FKQ | The crystal structure of a fragment of netrin-1 in complex with a fragment of draxin | x-ray diffraction | A | NAG, CA, SO4 | — |
| 7NDG | Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule… | electron microscopy | A, G, D | CA, NAG | 14 (best 0.67) |
| 7NDG | Cryo-EM structure of the ternary complex between netrin-1, neogenin and repulsive guidance molecule… | electron microscopy | A, G, D | CA, NAG | — |
| 7NE0 | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | x-ray diffraction | A | GU4, YYJ, NAG, CA, SO4 | 7 (best 0.67) |
| 7NE0 | Structure of the ternary complex between netrin-1, repulsive-guidance molecule-B (rgmb) and neogenin | x-ray diffraction | A | GU4, YYJ, NAG, CA, SO4 | — |
| 7NE1 | Structure of the complex between Netrin-1 and its receptor Neogenin | x-ray diffraction | A | GU4, YYJ, NAG, CA, NO3 | 6 (best 0.64) |
| 7NE1 | Structure of the complex between netrin-1 and its receptor neogenin | x-ray diffraction | A | GU4, YYJ, NAG, CA, NO3 | — |
| O95631 | AlphaFold monomer V2.0 prediction for netrin-1 (O95631) | predicted | A | — | 4 (best 0.49) |
Ligands
- CA · Calcium ion · in 9 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
- SO4 · Sulfate ion · in 5 records
- GU4 · 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose · in 4 records
- YYJ · 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose · in 4 records
- NO3 · Nitrate ion · in 2 records
- CL · Chloride ion · in 1 record
Experiment against prediction
- 7NE1 chain A against the predicted model O95631: TM-score 0.97, RMSD 1.25 Å
- 7NE1 chain A against the predicted model O95631: TM-score 0.97, RMSD 1.25 Å
- 4URT chain A against the predicted model O95631: TM-score 0.97, RMSD 1.32 Å
- 4URT chain A against the predicted model O95631: TM-score 0.97, RMSD 1.32 Å
- 7NDG chain A against the predicted model O95631: TM-score 0.94, RMSD 1.96 Å
- 7NDG chain A against the predicted model O95631: TM-score 0.94, RMSD 1.96 Å
- 7NE0 chain A against the predicted model O95631: TM-score 0.93, RMSD 2.23 Å
- 7NE0 chain A against the predicted model O95631: TM-score 0.93, RMSD 2.23 Å
- 6FKQ chain A against the predicted model O95631: TM-score 0.84, RMSD 3.30 Å
- 6FKQ chain A against the predicted model O95631: TM-score 0.84, RMSD 3.30 Å
Elsewhere
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