UniProt O95251
Histone acetyltransferase KAT7 (O95251)
Histone acetyltransferase KAT7 (UniProt O95251), EC 2.3.1.48: 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O95251
- Protein
- Histone acetyltransferase KAT7
- EC
- 2.3.1.48
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 13 · 5 records with a druggable one
Structures
17 records of O95251 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GK9 | Crystal structure of human HBO1 in complex with BRPF2 | x-ray diffraction | A | ZN, ACO | — |
| 5GK9 | Crystal structure of human HBO1 in complex with BRPF2 | x-ray diffraction | A | — | — |
| 6MAJ | HBO1 is required for the maintenance of leukaemia stem cells | x-ray diffraction | A | ZN, JAV | 2 (best 0.66) |
| 6MAJ | HBO1 is required for the maintenance of leukaemia stem cells | x-ray diffraction | A | ZN, JAV | — |
| 6MAK | HBO1 is required for the maintenance of leukaemia stem cells | x-ray diffraction | A | ZN, ACO | 3 (best 0.69) |
| 6MAK | HBO1 is required for the maintenance of leukaemia stem cells | x-ray diffraction | A | ZN, ACO | — |
| 7D0O | Crystal structure of human HBO1-BRPF2 in apo form | x-ray diffraction | A | ZN | 3 (best 0.63) |
| 7D0O | Crystal structure of human HBO1-BRPF2 in apo form | x-ray diffraction | A | ZN | — |
| 7D0P | Crystal structure of human HBO1-BRPF2 in complex with propionyl-coenzyme A | x-ray diffraction | A | 1VU, ZN | — |
| 7D0P | Crystal structure of human HBO1-BRPF2 in complex with propionyl- coenzyme a | — | — | — | |
| 7D0Q | Crystal structure of human HBO1-BRPF2 in complex with butyryl-coenzyme A | x-ray diffraction | A | ZN, BCO, CL | 3 (best 0.69) |
| 7D0Q | Crystal structure of human HBO1-BRPF2 in complex with butyryl-coenzyme a | x-ray diffraction | A | ZN, BCO, CL | — |
| 7D0R | Crystal structure of human HBO1-BRPF2 in complex with crotonoyl-coenzyme A | x-ray diffraction | A | ZN, COO | 2 (best 0.69) |
| 7D0R | Crystal structure of human HBO1-BRPF2 in complex with crotonoyl- coenzyme a | x-ray diffraction | A | ZN, COO | — |
| 7D0S | Crystal structure of human HBO1-BRPF2 in complex with succinyl-coenzyme A | x-ray diffraction | A | SCA, ZN | — |
| 7D0S | Crystal structure of human HBO1-BRPF2 in complex with succinyl- coenzyme a | x-ray diffraction | A | SCA, ZN | — |
| O95251 | AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT7 (O95251) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 14 records
- ACO · Acetyl coenzyme *A · in 3 records
- BCO · Butyryl Coenzyme A · in 2 records
- CL · Chloride ion · in 2 records
- COO · Crotonyl coenzyme A · in 2 records
- JAV · 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide · in 2 records
- SCA · Succinyl-coenzyme A · in 2 records
- 1VU · propionyl Coenzyme A · in 1 record
Experiment against prediction
- 5GK9 chain A against the predicted model O95251: TM-score 0.99, RMSD 0.59 Å
- 5GK9 chain A against the predicted model O95251: TM-score 0.99, RMSD 0.59 Å
- 6MAK chain A against the predicted model O95251: TM-score 0.99, RMSD 0.66 Å
- 6MAK chain A against the predicted model O95251: TM-score 0.99, RMSD 0.66 Å
- 6MAJ chain A against the predicted model O95251: TM-score 0.99, RMSD 0.66 Å
- 6MAJ chain A against the predicted model O95251: TM-score 0.99, RMSD 0.66 Å
- 7D0O chain A against the predicted model O95251: TM-score 0.99, RMSD 0.70 Å
- 7D0O chain A against the predicted model O95251: TM-score 0.99, RMSD 0.70 Å
- 7D0R chain A against the predicted model O95251: TM-score 0.99, RMSD 0.79 Å
- 7D0R chain A against the predicted model O95251: TM-score 0.99, RMSD 0.79 Å
Elsewhere
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