MolNFT v1 · #156632 · protein
HBO1 is required for the maintenance of leukaemia stem cells
6MAK · Histone acetyltransferase KAT7: “HBO1 is required for the maintenance of leukaemia stem cells”. X-ray diffraction, 2 ligands (ACO, ZN), 3 pockets (best druggability 0.69). MolNFT v1 #156632 on GenesisL1: 3D structure, binding sites…
- PDB
- 6MAK
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase KAT7; BRD1 protein
- EC
- 2.3.1.48
- UniProt
- O95251, Q86X06
- Ligands
- ACO, ZN
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase KAT7 (EC 2.3.1.48) | protein | 272 | 35% helix, 26% strand | O95251 |
| B | BRD1 protein | protein | 27 | 0% helix, 44% strand | Q86X06 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 303 | 0.69 | 0.83 | 38 | ACO |
| 2 | 141 | 0.47 | 0.78 | 25 | empty |
| 3 | 60 | 0.29 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 946 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 6MAK · HBO1 is required for the maintenance of leukaemia stem cells · the same entry in another collection · chain A against A, TM-score 1.00
- O95251 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT7 (O95251) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95251
- Every structure of UniProt Q86X06
- Elsewhere: RCSB PDB 6MAK · PDBe 6MAK · UniProt O95251 · UniProt Q86X06
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