UniProt O94768
Serine/threonine-protein kinase 17B (O94768)
Serine/threonine-protein kinase 17B (UniProt O94768), EC 2.7.11.1: 17 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O94768
- Protein
- Serine/threonine-protein kinase 17B
- EC
- 2.7.11.1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 17 · 9 records with a druggable one
Structures
18 records of O94768 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LM0 | Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) | x-ray diffraction | A | — | — |
| 3LM0 | Crystal structure of human SERINE/THREONINE kinase 17B (STK17B) | x-ray diffraction | A | — | — |
| 3LM5 | Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin | x-ray diffraction | A | — | — |
| 3LM5 | Crystal structure of human SERINE/THREONINE kinase 17B (STK17B) in complex with quercetin | x-ray diffraction | A | — | — |
| 6QF4 | X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP… | x-ray diffraction | A | MG, CL, ADP | 3 (best 0.65) |
| 6QF4 | X-ray structure of human SERINE/THREONINE kinase 17B (STK17B) aka DRAK2 in complex with ADP… | x-ray diffraction | A | MG, CL, ADP | — |
| 6Y6F | Crystal structure of STK17B (DRAK2) in complex with PKIS43 | x-ray diffraction | A | OD2 | 3 (best 0.66) |
| 6Y6F | Crystal structure of STK17B (DRAK2) in complex with PKIS43 | x-ray diffraction | A | OD2 | — |
| 6Y6H | Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe | x-ray diffraction | A | OBW | 1 (best 0.69) |
| 6Y6H | Crystal structure of STK17B (DRAK2) in complex with unc-ap-194 probe | x-ray diffraction | A | OBW | — |
| 6ZJF | Crystal structure of STK17B (DRAK2) in complex with AP-229 | x-ray diffraction | A | QM2 | 1 (best 0.73) |
| 6ZJF | Crystal structure of STK17B (DRAK2) in complex with ap-229 | x-ray diffraction | A | QM2 | — |
| 7AKG | Crystal structure of STK17B with bound dovitinib | x-ray diffraction | A | 38O | 1 (best 0.71) |
| 7AKG | Crystal structure of STK17B with bound dovitinib | x-ray diffraction | A | 38O | — |
| 7Q7C | Room temperature structure of the human Serine/Threonine Kinase 17B (STK17B/DRAK2) in complex with… | x-ray diffraction | A | MG, ADP | 2 (best 0.65) |
| 7Q7D | Room temperature structure of the human Serine/Threonine Kinase 17B (STK17B/DRAK2) in complex with… | x-ray diffraction | A | ATP, MG | 1 (best 0.68) |
| 7Q7E | Room temperature structure of the human Serine/Threonine Kinase 17B (STK17B/DRAK2) in complex with… | x-ray diffraction | A | ATP, MG | 1 (best 0.67) |
| O94768 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 17B (O94768) | predicted | A | — | 4 (best 0.66) |
Ligands
- MG · Magnesium ion · in 5 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- 38O · 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- CL · Chloride ion · in 2 records
- OBW · 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid · in 2 records
- OD2 · 2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid · in 2 records
- QM2 · 2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid · in 2 records
Experiment against prediction
- 3LM5 chain A against the predicted model O94768: TM-score 0.97, RMSD 0.80 Å
- 3LM5 chain A against the predicted model O94768: TM-score 0.97, RMSD 0.80 Å
- 3LM0 chain A against the predicted model O94768: TM-score 0.97, RMSD 0.82 Å
- 3LM0 chain A against the predicted model O94768: TM-score 0.97, RMSD 0.82 Å
- 7Q7C chain A against the predicted model O94768: TM-score 0.97, RMSD 0.86 Å
- 6QF4 chain A against the predicted model O94768: TM-score 0.97, RMSD 1.02 Å
- 6QF4 chain A against the predicted model O94768: TM-score 0.97, RMSD 1.02 Å
- 6Y6F chain A against the predicted model O94768: TM-score 0.96, RMSD 1.02 Å
- 6Y6F chain A against the predicted model O94768: TM-score 0.96, RMSD 1.02 Å
- 6Y6H chain A against the predicted model O94768: TM-score 0.96, RMSD 1.01 Å
Elsewhere
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