MolNFT v1 · #70493 · protein
Crystal structure of human SERINE/THREONINE kinase 17B (STK17B) in complex with quercetin
3LM5 · SERINE/THREONINE-protein kinase 17B: “Crystal structure of human SERINE/THREONINE kinase 17B (STK17B) in complex with quercetin”. X-ray diffraction, 1 ligand (QUE), 1 pocket (best druggability 0.67). MolNFT v1 #70493 on GenesisL1…
- PDB
- 3LM5
- Type
- protein
- Length
- 274 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase 17B
- EC
- 2.7.11.1
- UniProt
- O94768
- Ligands
- QUE
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase 17B (EC 2.7.11.1) | protein | 274 | 38% helix, 22% strand | O94768 |
Ligands and binding sites
- QUE · 3,5,7,3',4'-pentahydroxyflavone · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 491 | 0.67 | 0.78 | 58 | QUE |
Compared structures
- 3LM5 · Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin · the same entry in another collection · chain A against A, TM-score 1.00
- O94768 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 17B (O94768) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94768
- Elsewhere: RCSB PDB 3LM5 · PDBe 3LM5 · UniProt O94768
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