UniProt O94759
Transient receptor potential cation channel subfamily M member 2 (O94759)
Transient receptor potential cation channel subfamily M member 2 (UniProt O94759): 25 experimental structures on GenesisL1, 8 ligands bound, 228 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O94759
- Protein
- Transient receptor potential cation channel subfamily M member 2
- Experimental structures
- 25
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 228 · 12 records with a druggable one
Structures
25 records of O94759 in the MolNFT archive: 25 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6MIX | Human TRPM2 ion channel in apo state | electron microscopy | A, B, C, D | — | 20 (best 0.88) |
| 6MIX | Human TRPM2 ion channel in apo state | electron microscopy | A, B, C, D | — | — |
| 6MIZ | Human TRPM2 ion channel in an ADPR-bound state | electron microscopy | A, B, C, D | — | 20 (best 0.88) |
| 6MIZ | Human TRPM2 ion channel in an adpr-bound state | electron microscopy | A, B, C, D | — | — |
| 6MJ2 | Human TRPM2 ion channel in a calcium- and ADPR-bound state | electron microscopy | A, B, C, D | CA | 20 (best 0.87) |
| 6MJ2 | Human TRPM2 ion channel in a calcium- and adpr-bound state | electron microscopy | A, B, C, D | CA | — |
| 6PUO | Human TRPM2 in the apo state | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6PUO | Human TRPM2 in the apo state | electron microscopy | A, B, C, D | — | — |
| 6PUR | Human TRPM2 bound to ADPR | electron microscopy | A, B, C, D | APR | 20 (best 0.84) |
| 6PUR | Human TRPM2 bound to adpr | electron microscopy | A, B, C, D | APR | — |
| 6PUS | Human TRPM2 bound to ADPR and calcium | electron microscopy | A, C, D, B | APR, CA | 20 (best 0.83) |
| 6PUS | Human TRPM2 bound to adpr and calcium | electron microscopy | A, C, D, B | APR, CA | — |
| 6PUU | Human TRPM2 bound to 8-Br-cADPR and calcium | electron microscopy | A, B, C, D | CV1, CA | 20 (best 0.82) |
| 6PUU | Human TRPM2 bound to 8-br-cadpr and calcium | electron microscopy | A, B, C, D | CV1, CA | — |
| 7VQ1 | Structure of Apo-hsTRPM2 channel | electron microscopy | A, B, C, D | — | 20 (best 0.88) |
| 7VQ1 | Structure of apo-HSTRPM2 channel | electron microscopy | A, B, C, D | — | — |
| 7VQ2 | Structure of Apo-hsTRPM2 channel TM domain | electron microscopy | A, B, C, D | — | — |
| 7VQ2 | Structure of apo-HSTRPM2 channel tm domain | electron microscopy | A, B, C, D | — | — |
| 8E6Q | Human TRPM2 ion channel in 1 mM ADPR | electron microscopy | A, B, C, D | APR | — |
| 8E6R | Human TRPM2 ion channel in 1 mM dADPR | electron microscopy | A, B, C, D | APR, AR6 | 20 (best 0.89) |
| 8E6S | Human TRPM2 ion channel in 1 mM dADPR and Ca2+ | electron microscopy | A, B, C, D | APR, DAT, ZN, CA | 20 (best 0.87) |
| 8E6T | Human TRPM2 ion channel in 1 mM BR-ADPR | electron microscopy | A, B, C, D | UOO | 20 (best 0.89) |
| 8E6U | Human TRPM2 ion channel in 1 mM F-dADPR | electron microscopy | A, B, C, D | UOZ | — |
| 8E6V | MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement) | electron microscopy | A | APR, ZN | 8 (best 0.73) |
| O94759 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M… | — | — | — |
Ligands
- APR · Adenosine-5-diphosphoribose · in 8 records
- CA · Calcium ion · in 7 records
- CV1 · (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14, 15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13, 16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide · in 2 records
- ZN · Zinc ion · in 2 records
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · in 1 record
- DAT · 2'-deoxyadenosine-5'-diphosphate · in 1 record
- UOO · (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) · in 1 record
- UOZ · [(2R,3S,5R)-5-(6-amino-8-phenyl-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) · in 1 record
Elsewhere
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