MolNFT v1 · #156915 · protein

Human TRPM2 ion channel in an adpr-bound state

6MIZ · Transient receptor potential cation channel subfamily M…: “Human TRPM2 ion channel in an adpr-bound state”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #156915 on GenesisL1: 3D structure, binding sites and…

PDB: 6MIZ
Type: protein
Length: 5,348 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 2
UniProt: O94759
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 38% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 2	protein	1337	38% helix, 7% strand	O94759

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	763	0.88	0.90	102	empty
2	854	0.86	0.87	87	empty
3	983	0.85	0.85	86	empty
4	505	0.84	0.90	67	empty
5	629	0.83	0.87	72	empty

Interfaces

6 interfaces between chains.

A–B · 2568 Å² buried · 24 hydrogen bonds · protein-protein
B–C · 2555 Å² buried · 22 hydrogen bonds · protein-protein
A–D · 2549 Å² buried · 22 hydrogen bonds · protein-protein
C–D · 2548 Å² buried · 22 hydrogen bonds · protein-protein
A–C · 45 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6MIZ · Human TRPM2 ion channel in an ADPR-bound state · the same entry in another collection · chain A against A, TM-score 1.00
O94759 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94759
Elsewhere: RCSB PDB 6MIZ · PDBe 6MIZ · UniProt O94759

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