MolNFT v1 · #189668 · protein

Structure of apo-HSTRPM2 channel tm domain

7VQ2 · Transient receptor potential cation channel subfamily M…: “Structure of apo-HSTRPM2 channel tm domain”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #189668 on GenesisL1: 3D structure, binding sites and…

PDB: 7VQ2
Type: protein
Length: 1,416 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 2
UniProt: O94759
Pockets: 20 · best druggability 0.89

Structure

electron microscopy · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 2	protein	354	69% helix, 0% strand	O94759

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1006	0.89	0.90	128	empty
2	772	0.84	0.86	73	empty
3	321	0.78	0.88	42	empty
4	323	0.77	0.88	40	empty
5	337	0.77	0.87	40	empty

Interfaces

6 interfaces between chains.

A–D · 2877 Å² buried · 26 hydrogen bonds · protein-protein
B–C · 2875 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 2874 Å² buried · 26 hydrogen bonds · protein-protein
A–B · 2870 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 830 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7VQ2 · Structure of Apo-hsTRPM2 channel TM domain · the same entry in another collection · chain B against B, TM-score 1.00
O94759 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94759
Elsewhere: RCSB PDB 7VQ2 · PDBe 7VQ2 · UniProt O94759

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