UniProt O94609
Ubiquitin-activating enzyme E1 1 (O94609)
Ubiquitin-activating enzyme E1 1 (UniProt O94609), EC 6.2.1.45: 29 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 282 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O94609
- Protein
- Ubiquitin-activating enzyme E1 1
- EC
- 6.2.1.45
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 282 · 18 records with a druggable one
Structures
30 records of O94609 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4II2 | Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4… | x-ray diffraction | A | — | — |
| 4II2 | Crystal structure of ubiquitin activating enzyme 1 (UBA1) in complex with the ub E2 UBC4… | x-ray diffraction | A | — | — |
| 4II3 | Crystal structure of S. pombe Ubiquitin activating enzyme 1 (Uba1) in complex with ubiquitin and… | x-ray diffraction | A, C | — | — |
| 4II3 | Crystal structure of S. pombe ubiquitin activating enzyme 1 (UBA1) in complex with ubiquitin and… | x-ray diffraction | A, C | — | — |
| 5KNL | Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin | x-ray diffraction | A, D | SO4 | — |
| 5KNL | Crystal structure of S. pombe ubiquitin E1 (UBA1) in complex with UBC15 and ubiquitin | x-ray diffraction | A, D | SO4 | — |
| 5UM6 | Crystal Structure of S. pombe Uba1 in a closed conformation | x-ray diffraction | A | SO4, 8EA, 8E7 | — |
| 5UM6 | Crystal structure of S. pombe UBA1 in a closed conformation | x-ray diffraction | A | SO4, 8EA, 8E7 | — |
| 6O82 | S. pombe ubiquitin E1 complex with a ubiquitin-AMP mimic | x-ray diffraction | A, C | MG, POP, SO4, JZU | — |
| 6O82 | S. pombe ubiquitin E1 complex with a ubiquitin-AMP mimic | x-ray diffraction | A, C | MG, POP, SO4, JZU | — |
| 6O83 | S. pombe ubiquitin E1~ubiquitin-AMP tetrahedral intermediate mimic | x-ray diffraction | A, C | CA, VMX | — |
| 6O83 | S. pombe ubiquitin E1~UBIQUITIN-AMP tetrahedral intermediate mimic | x-ray diffraction | A, C | CA, VMX | — |
| 9B5C | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - consensus… | electron microscopy | A | MG, ATP, A1AIV | 17 (best 0.78) |
| 9B5D | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 17 (best 0.78) |
| 9B5E | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 16 (best 0.77) |
| 9B5F | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 1… | electron microscopy | A | MG, ATP, A1AIV | 13 (best 0.79) |
| 9B5G | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 2… | electron microscopy | A | MG, ATP, A1AIV | 14 (best 0.79) |
| 9B5I | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 4… | electron microscopy | A | MG, POP, AMP, A1AIV | 20 (best 0.79) |
| 9B5J | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 5… | electron microscopy | A | AMP, A1AIV | 18 (best 0.78) |
| 9B5K | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 19 (best 0.73) |
| 9B5L | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | A | AMP, A1AIV | 17 (best 0.78) |
| 9B5N | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.74) |
| 9B5O | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.75) |
| 9B5Q | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 2… | electron microscopy | A | MG, ATP, A1AIV | 13 (best 0.74) |
| 9B5R | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 3… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.74) |
| 9B5S | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 4… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.76) |
| 9B5U | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 16 (best 0.75) |
| 9B5W | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.79) |
| 9B5X | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | A | MG, ATP, A1AIV | 15 (best 0.76) |
| O94609 | AlphaFold monomer V2.0 prediction for ubiquitin-activating enzyme E1 1 (O94609) | predicted | A | — | 12 (best 0.74) |
Ligands
- A1AIV · 4-aminobutanenitrile · in 17 records
- MG · Magnesium ion · in 17 records
- ATP · Adenosine-5'-triphosphate · in 14 records
- SO4 · Sulfate ion · in 6 records
- AMP · Adenosine monophosphate · in 3 records
- POP · Pyrophosphate 2- · in 3 records
- 8E7 · 2-(decylamino)ethane-1-thiol · in 2 records
- 8EA · N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine · in 2 records
- CA · Calcium ion · in 2 records
- JZU · 5'-deoxy-5'-(sulfamoylamino)adenosine · in 2 records
- VMX · 5'-{[(3-aminopropyl)sulfonyl]amino}-5'-deoxyadenosine · in 2 records
Experiment against prediction
- 4II3 chain A against the predicted model O94609: TM-score 0.99, RMSD 1.28 Å
- 4II3 chain A against the predicted model O94609: TM-score 0.99, RMSD 1.28 Å
- 6O82 chain C against the predicted model O94609: TM-score 0.99, RMSD 1.36 Å
- 6O82 chain C against the predicted model O94609: TM-score 0.99, RMSD 1.36 Å
- 4II3 chain C against the predicted model O94609: TM-score 0.99, RMSD 1.39 Å
- 4II3 chain C against the predicted model O94609: TM-score 0.99, RMSD 1.39 Å
- 6O82 chain A against the predicted model O94609: TM-score 0.98, RMSD 1.41 Å
- 6O82 chain A against the predicted model O94609: TM-score 0.98, RMSD 1.41 Å
- 9B5D chain A against the predicted model O94609: TM-score 0.98, RMSD 1.53 Å
- 9B5C chain A against the predicted model O94609: TM-score 0.98, RMSD 1.54 Å
Elsewhere
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