UniProt O79876
Cytochrome c oxidase subunit 1 (O79876)
Cytochrome c oxidase subunit 1 (UniProt O79876), EC 7.1.1.9: 6 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O79876
- Protein
- Cytochrome c oxidase subunit 1
- EC
- 7.1.1.9
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 31 · 6 records with a druggable one
Structures
7 records of O79876 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8UGH | In-situ structure of typeA supercomplex with lipids in respiratory chain (composite) | electron microscopy | 4A | HEA, CU, MG, NA, PGV, CDL | 2 (best 0.91) |
| 8UGI | High resolution in-situ structure of typeA supercomplex in respiratory chain (I1III2IV1,composite) | electron microscopy | 4A | PGV, HEA, CU, MG, NA, CDL | 2 (best 0.91) |
| 8UGJ | In-situ structure of typeB supercomplex in respiratory chain (composite) | electron microscopy | 4A, 8A | PGV, HEA, CU, MG, NA, CDL | 4 (best 0.92) |
| 8UGL | High resolution in-situ structure of complex IV in respiratory supercomplex | electron microscopy | 4A | PGV, HEA, CU, MG, NA, CDL | 17 (best 0.91) |
| 8UGN | In-situ structure of typeO supercomplex in respiratory chain (composite) | electron microscopy | 4A, 8A | PGV, HEA, CU, MG, NA, PSC | 4 (best 0.92) |
| 8UGR | In-situ structure of typeX supercomplex in respiratory chain (composite) | electron microscopy | 4A, 8A | PGV, HEA, CU, MG, NA, CDL | 2 (best 0.91) |
| O79876 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 1 (O79876) | predicted | A | — | — |
Ligands
- CDL · Cardiolipin · in 6 records
- CU · Copper (II) ion · in 6 records
- HEA · Heme-A · in 6 records
- MG · Magnesium ion · in 6 records
- NA · Sodium ion · in 6 records
- PEK · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5E,8E,11E,14E)-icosa-5,8, 11,14-tetraenoate · in 6 records
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · in 6 records
- PSC · (7R,17E,20E)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide · in 6 records
Experiment against prediction
- 8UGL chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.35 Å
- 8UGI chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.35 Å
- 8UGN chain 8A against the predicted model O79876: TM-score 1.00, RMSD 0.48 Å
- 8UGJ chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.49 Å
- 8UGN chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.49 Å
- 8UGJ chain 8A against the predicted model O79876: TM-score 1.00, RMSD 0.50 Å
- 8UGH chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.50 Å
- 8UGR chain 4A against the predicted model O79876: TM-score 1.00, RMSD 0.55 Å
- 8UGR chain 8A against the predicted model O79876: TM-score 1.00, RMSD 0.55 Å
Elsewhere
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