UniProt O79874
NADH-ubiquinone oxidoreductase chain 1 (O79874)
NADH-ubiquinone oxidoreductase chain 1 (UniProt O79874), EC 1.6.5.3, 7.1.1.2: 61 experimental structures on GenesisL1, 5 ligands bound, 130 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O79874
- Protein
- NADH-ubiquinone oxidoreductase chain 1
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 61
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 130 · 41 records with a druggable one
Structures
61 records of O79874 in the MolNFT archive: 61 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | e | — | 1 (best 0.89) |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | r | PLX, PEE | 4 (best 0.90) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.88) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.91) |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.91) |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.90) |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2H | Active state complex I from DQ-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.89) |
| 7V2H | Active state complex I from dq-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2K | Deactive state complex I from DQ-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.88) |
| 7V2K | Deactive state complex I from dq-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | s | PEE, PLX, UQ, CDL, UQ1 | 4 (best 0.89) |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | s | PEE, PLX, UQ, CDL, UQ1 | — |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.91) |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V31 | Active state complex I from rote dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.90) |
| 7V31 | Active state complex I from rotenone dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V32 | Deactive state complex I from rotenone dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V33 | Active state complex I from rote -NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.88) |
| 7V33 | Active state complex I from rotenone-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V3M | Deactive state complex I from rote -NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7V3M | Deactive state complex I from rotenone-NADH dataset | electron microscopy | s | PEE, PLX, CDL, UQ | — |
| 7VBL | Membrane arm of active state ci from dq-NADH dataset | electron microscopy | s | PEE, CDL, UQ | — |
| 7VBP | Membrane arm of deactive state CI from DQ-NADH dataset | electron microscopy | s | PEE, UQ | — |
| 7VBP | Membrane arm of deactive state ci from dq-NADH dataset | electron microscopy | s | PEE, UQ | — |
| 7VC0 | Membrane arm of active state CI from Rote -NADH dataset | electron microscopy | s | PEE, CDL, UQ | 2 (best 0.91) |
| 7VC0 | Membrane arm of active state ci from rotenone-NADH dataset | electron microscopy | s | PEE, CDL, UQ | — |
| 7VWL | Membrane arm of deactive state CI from rote -NADH dataset | electron microscopy | s | PEE, UQ | 2 (best 0.90) |
| 7VWL | Membrane arm of deactive state ci from rotenone-NADH dataset | electron microscopy | s | PEE, UQ | — |
| 7VXS | Membrane arm of active state CI from Q10 dataset | electron microscopy | s | PEE, CDL | 2 (best 0.84) |
| 7VY1 | Membrane arm of deactive state CI from Q10 dataset | electron microscopy | s | PEE, UQ | 2 (best 0.89) |
| 7VY9 | Membrane arm of active state CI from Q10-NADH dataset | electron microscopy | s | PEE, CDL, UQ | 2 (best 0.91) |
| 7VYE | Membrane arm of deactive state CI from Q10-NADH dataset | electron microscopy | s | PEE, UQ | 2 (best 0.89) |
| 7VYS | Membrane arm of active state CI from Q1-NADH dataset | electron microscopy | s | PEE, CDL, UQ | 1 (best 0.90) |
| 7VZW | Active state CI from Q10 dataset, Subclass 2 | electron microscopy | s | PEE, PLX, UQ, CDL | 3 (best 0.91) |
| 7W0H | Deactive state CI from Q10 dataset, Subclass 2 | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.89) |
| 7W0R | Active state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, UQ, CDL | 4 (best 0.89) |
| 7W1O | Deactive state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | s | PEE, UQ | 4 (best 0.89) |
| 7W1T | Active state CI from Rote dataset, Subclass 1 | electron microscopy | s | PEE, UQ, PLX, CDL | 4 (best 0.90) |
| 7W1U | Active state CI from Rote dataset, Subclass 2 | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.88) |
| 7W1V | Active state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.89) |
| 7W20 | Active state CI from Rote -NADH dataset, Subclass 3 | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.88) |
| 7W2K | Deactive state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, UQ | 3 (best 0.90) |
| 7W2L | Deactive state CI from Rote -NADH dataset, Subclass 2 | electron microscopy | s | PEE, CDL, UQ | 3 (best 0.91) |
| 7W2R | Active state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.89) |
| 7W2U | Active state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.89) |
| 7W2Y | Active state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.88) |
| 7W31 | Deactive state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, CDL, UQ | 4 (best 0.90) |
| 7W32 | Deactive state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | s | PLX, CDL, PEE, UQ | 4 (best 0.90) |
| 7W35 | Deactive state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | s | PEE, PLX, UQ | 4 (best 0.89) |
| 7W4C | Active state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | s | PEE, PLX, UQ, CDL | 3 (best 0.89) |
| 7W4E | Active state CI from Q1-NADH dataset, Subclass 3 | electron microscopy | s | PEE, PLX, UQ, CDL | 2 (best 0.89) |
| 7W4F | Active state CI from Q1-NADH dataset, Subclass 4 | electron microscopy | s | PEE, UQ1, PLX, CDL, UQ | 3 (best 0.89) |
| 7W4G | Active state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | s | PEE, PLX, UQ1, CDL, UQ | 3 (best 0.89) |
| 7W4J | Deactive state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | s | CDL, PEE, UQ | — |
| 7W4N | Deactive state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | s | PEE, PLX, CDL, UQ | 3 (best 0.91) |
| 7W4Q | Deactive state CI from Q1-NADH dataset, Subclass 6 | electron microscopy | s | PEE, CDL, PLX, UQ | 5 (best 0.90) |
1 record more on the page itself.
Ligands
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 59 records
- UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer · in 57 records
- CDL · Cardiolipin · in 49 records
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 44 records
- UQ1 · Ubiquinone-1 · in 4 records
Elsewhere
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