UniProt O76083
O76083
O76083 (UniProt O76083): 44 experimental structures on GenesisL1, 6 ligands bound. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O76083
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 6
Structures
44 records of O76083 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YY2 | Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX | x-ray diffraction | A, B | — | — |
| 2YY2 | Crystal structure of the human phosphodiesterase 9A catalytic domain complexed with ibmx | x-ray diffraction | A, B | — | — |
| 3DY8 | Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex) | x-ray diffraction | A, B | — | — |
| 3DY8 | Human phosphodiesterase 9 in complex with product 5'-gmp (E+P complex) | x-ray diffraction | A, B | — | — |
| 3DYL | human phosphdiesterase 9 substrate complex (ES complex) | x-ray diffraction | A, B | — | — |
| 3DYL | Human phosphdiesterase 9 substrate complex (es complex) | x-ray diffraction | A, B | — | — |
| 3DYN | human phosphodiestrase 9 in complex with cGMP (Zn inhibited) | x-ray diffraction | A, B | — | — |
| 3DYN | Human phosphodiestrase 9 in complex with cgmp (zn inhibited) | x-ray diffraction | A, B | — | — |
| 3DYQ | human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP | x-ray diffraction | A, B | — | — |
| 3DYQ | Human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cgmp | x-ray diffraction | A, B | — | — |
| 3DYS | human phosphodiestrase-5'GMP complex (EP), produced by soaking with 20mM cGMP+20 mM MnCl2+20 mM… | x-ray diffraction | A, B | — | — |
| 3DYS | Human phosphodiestrase-5'GMP complex (ep), produced by soaking with 20MM CGMP+20 mm MNCL2+20 mm… | x-ray diffraction | A, B | — | — |
| 3JSI | Human phosphodiesterase 9 in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 3JSI | Human phosphodiesterase 9 in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 3JSW | Human PDE9 in complex with selective inhibitor | x-ray diffraction | A, B | — | — |
| 3JSW | Human PDE9 in complex with selective inhibitor | x-ray diffraction | A, B | — | — |
| 3K3E | Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3K3E | Crystal structure of the PDE9A catalytic domain in complex with (R)- BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3K3H | Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3K3H | Crystal structure of the PDE9A catalytic domain in complex with (S)- BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3N3Z | Crystal structure of PDE9A (E406A) mutant in complex with IBMX | x-ray diffraction | A, B | — | — |
| 3N3Z | Crystal structure of PDE9A (E406A) mutant in complex with ibmx | x-ray diffraction | A, B | — | — |
| 3QI3 | Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3QI3 | Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691 | x-ray diffraction | A, B | — | — |
| 3QI4 | Crystal structure of PDE9A(Q453E) in complex with IBMX | x-ray diffraction | A, B | — | — |
| 3QI4 | Crystal structure of PDE9A(Q453E) in complex with ibmx | x-ray diffraction | A, B | — | — |
| 4E90 | Human phosphodiesterase 9 in complex with inhibitors | x-ray diffraction | A, B | — | — |
| 4E90 | Human phosphodiesterase 9 in complex with inhibitors | x-ray diffraction | A, B | — | — |
| 4G2J | Human pde9 in complex with selective compound | x-ray diffraction | A, B | — | — |
| 4G2J | Human PDE9 in complex with selective compound | x-ray diffraction | A, B | — | — |
| 4G2L | Human PDE9 in complex with selective compound | x-ray diffraction | A, B | — | — |
| 4G2L | Human PDE9 in complex with selective compound | x-ray diffraction | A, B | — | — |
| 4GH6 | Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28 | x-ray diffraction | A, B | — | — |
| 4GH6 | Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28 | x-ray diffraction | A, B | — | — |
| 4Y86 | Crystal structure of PDE9 in complex with racemic inhibitor C33 | x-ray diffraction | A, B | — | — |
| 4Y86 | Crystal structure of PDE9 in complex with racemic inhibitor C33 | x-ray diffraction | A, B | — | — |
| 4Y87 | Crystal structure of phosphodiesterase 9 in complex with (R)-C33… | x-ray diffraction | A, B | — | — |
| 4Y87 | Crystal structure of phosphodiesterase 9 in complex with (R)-C33 (6… | x-ray diffraction | A, B | — | — |
| 4Y8C | Crystal structure of phosphodiesterase 9 in complex with (S)-C33 | x-ray diffraction | A, B | — | — |
| 4Y8C | Crystal structure of phosphodiesterase 9 in complex with (S)-C33 | x-ray diffraction | A, B | — | — |
| 6A3N | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2 | x-ray diffraction | A, B | ZN, MG, 9Q9 | — |
| 6LZZ | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4A | x-ray diffraction | A, B | ZN, MG, EZU | — |
| 8BPY | X-RAY STRUCTURE OF PDE9A IN COMPLEX WITH Inhibitor 13A | x-ray diffraction | A, B | ZN, MG, NA, R4I | — |
| O76083 | AlphaFold monomer V2.0 prediction for high affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9A… | — | — | — |
Ligands
- MG · Magnesium ion · in 3 records
- ZN · Zinc ion · in 3 records
- 9Q9 · 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3, 4-d]pyrimidin-4-one · in 1 record
- EZU · 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- NA · Sodium ion · in 1 record
- R4I · (8~{S})-6-[2-(2,3-dihydroindol-1-yl)-2-oxidanylidene-ethyl]-4-(4-methylphenyl)-2-oxidanylidene-8-propyl-1,5,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile · in 1 record
Elsewhere
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