UniProt O60701
UDP-glucose 6-dehydrogenase (O60701)
UDP-glucose 6-dehydrogenase (UniProt O60701), EC 1.1.1.22: 35 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 100 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O60701
- Protein
- UDP-glucose 6-dehydrogenase
- EC
- 1.1.1.22
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 100 · 7 records with a druggable one
Structures
36 records of O60701 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Q3E | Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2Q3E | Structure of human udp-glucose dehydrogenase complexed with NADH and udp-glucose | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2QG4 | Crystal structure of human UDP-glucose dehydrogenase product complex with UDP-glucuronate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2QG4 | Crystal structure of human udp-glucose dehydrogenase product complex with udp-glucuronate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ITK | Crystal structure of human UDP-glucose dehydrogenase Thr131Ala, apo form. | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3ITK | Crystal structure of human udp-glucose dehydrogenase THR131ALA, apo form. | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3KHU | Crystal structure of human UDP-glucose dehydrogenase Glu161Gln, in complex with thiohemiacetal… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3KHU | Crystal structure of human udp-glucose dehydrogenase GLU161GLN, in complex with thiohemiacetal… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3PRJ | Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3PRJ | Role of packing defects in the evolution of allostery and induced fit in human udp-glucose… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3PTZ | Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3PTZ | Role of packing defects in the evolution of allostery and induced fit in human udp-glucose… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3TDK | Crystal Structure of Human UDP-Glucose Dehydrogenase | x-ray diffraction | A, B, G, H, L, K, F, E, D, C, J, I | — | — |
| 3TDK | Crystal structure of human udp-glucose dehydrogenase | x-ray diffraction | A, B, G, H, L, K, F, E, D, C, J, I | — | — |
| 3TF5 | Structure of UDP-glucose dehydrogenase V132 deletion | x-ray diffraction | A, B, C | — | — |
| 3TF5 | Structure of udp-glucose dehydrogenase V132 deletion | x-ray diffraction | A, B, C | — | — |
| 4EDF | Dimeric hUGDH, K94E | x-ray diffraction | A, B, C, D | — | — |
| 4EDF | Dimeric hugdh, K94E | x-ray diffraction | A, B, C, D | — | — |
| 4RJT | Crystal Structure of Unliganded, Full Length hUGDH at pH 7.0 | x-ray diffraction | A, B, C | — | — |
| 4RJT | Crystal structure of unliganded, full length hugdh at pH 7.0 | x-ray diffraction | A, B, C | — | — |
| 5TJH | Hugdh A136M substitution | x-ray diffraction | A, B, C, D, E, F | POP, CL, UPG | — |
| 5VR8 | Human UDP-Glucose Dehydrogenase with UDP-Xylose Bound to the Co-enzyme Site | x-ray diffraction | A, B, C, D, E, F | UDX, ADP | 20 (best 0.78) |
| 5VR8 | Human udp-glucose dehydrogenase with udp-xylose bound to the co-enzyme site | x-ray diffraction | A, B, C, D, E, F | UDX, ADP | — |
| 5W4X | Truncated hUGDH | x-ray diffraction | A, B, C | — | 11 (best 0.71) |
| 5W4X | Truncated hugdh | x-ray diffraction | A, B, C | — | — |
| 6C4J | Ligand bound full length hUGDH with A104L substitution | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | NAD, UPG, CL, SO4 | 20 (best 0.80) |
| 6C4J | Ligand bound full length hugdh with A104L substitution | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | NAD, UPG, CL, SO4 | — |
| 6C4K | Full length hUGDH with A104L substitution in the absence of ligand | x-ray diffraction | A, B, C | PO4, NA | 10 (best 0.76) |
| 6C4K | Full length hugdh with A104L substitution in the absence of ligand | x-ray diffraction | A, B, C | PO4, NA | — |
| 6C58 | Human UDP-Glucose Dehydrogenase A225L substitutuion with UDP-xylose bound | x-ray diffraction | A, B, C, D, E, F | UDX, CL | — |
| 6C58 | Human udp-glucose dehydrogenase A225L substitutuion with udp-xylose bound | x-ray diffraction | A, B, C, D, E, F | UDX, CL | — |
| 6C5A | Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound | x-ray diffraction | A, B, C, D, E, F | NAI, UPG | 17 (best 0.80) |
| 6C5A | Human udp-glucose dehydrogenase with udp- glc and NADH bound | x-ray diffraction | A, B, C, D, E, F | NAI, UPG | — |
| 6C5Z | Human UDP-Glucose Dehydrogenase A225L substitutuion with UDP-glucose and NADH bound | x-ray diffraction | A, B, C, D, E, F | NAI, UPG | 19 (best 0.80) |
| 6C5Z | Human udp-glucose dehydrogenase A225L substitutuion with udp-glucose and NADH bound | x-ray diffraction | A, B, C, D, E, F | NAI, UPG | — |
| O60701 | AlphaFold monomer V2.0 prediction for udp-glucose 6-dehydrogenase (O60701) | predicted | A | — | 3 (best 0.77) |
Ligands
- UPG · Uridine-5'-diphosphate-glucose · in 7 records
- CL · Chloride ion · in 5 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 4 records
- UDX · Uridine-5'-diphosphate-xylopyranose · in 4 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- NA · Sodium ion · in 2 records
- NAD · Nicotinamide-adenine-dinucleotide · in 2 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- POP · Pyrophosphate 2- · in 1 record
Experiment against prediction
- 6C5A chain A against the predicted model O60701: TM-score 0.99, RMSD 0.56 Å
- 6C5Z chain A against the predicted model O60701: TM-score 0.99, RMSD 0.59 Å
- 2Q3E chain A against the predicted model O60701: TM-score 0.99, RMSD 0.61 Å
- 2Q3E chain A against the predicted model O60701: TM-score 0.99, RMSD 0.61 Å
- 2Q3E chain D against the predicted model O60701: TM-score 0.99, RMSD 0.62 Å
- 2Q3E chain D against the predicted model O60701: TM-score 0.99, RMSD 0.62 Å
- 2QG4 chain B against the predicted model O60701: TM-score 0.99, RMSD 0.63 Å
- 2QG4 chain B against the predicted model O60701: TM-score 0.99, RMSD 0.63 Å
- 6C4J chain J against the predicted model O60701: TM-score 0.99, RMSD 0.63 Å
- 6C5A chain F against the predicted model O60701: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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