MolNFT v1 · #79837 · protein
Structure of udp-glucose dehydrogenase V132 deletion
3TF5 · Udp-glucose 6-dehydrogenase: “Structure of udp-glucose dehydrogenase V132 deletion”. X-ray diffraction, 10 pockets (best druggability 0.77). MolNFT v1 #79837 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3TF5
- Type
- protein
- Length
- 1,373 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose 6-dehydrogenase
- EC
- 1.1.1.22
- UniProt
- O60701
- Pockets
- 10 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose 6-dehydrogenase (EC 1.1.1.22) | protein | 458 | 46% helix, 15% strand | O60701 |
| B | Udp-glucose 6-dehydrogenase (EC 1.1.1.22) | protein | 457 | 46% helix, 15% strand | O60701 |
| C | Udp-glucose 6-dehydrogenase (EC 1.1.1.22) | protein | 458 | 45% helix, 15% strand | O60701 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 951 | 0.77 | 0.79 | 91 | empty |
| 2 | 1183 | 0.77 | 0.79 | 118 | empty |
| 3 | 1126 | 0.76 | 0.78 | 107 | empty |
| 4 | 210 | 0.60 | 0.81 | 33 | empty |
| 5 | 119 | 0.53 | 0.82 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 813 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 810 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 805 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60701
- Elsewhere: RCSB PDB 3TF5 · PDBe 3TF5 · UniProt O60701
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