UniProt O60563
Cyclin-T1 (O60563)
Cyclin-T1 (UniProt O60563): 51 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60563
- Protein
- Cyclin-T1
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 13 · 2 records with a druggable one
Structures
52 records of O60563 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2PK2 | Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat | x-ray diffraction | A, B, C, D | — | — |
| 2PK2 | Cyclin box structure of the P-tefb subunit cyclin T1 derived from a fusion complex with eiav tat | x-ray diffraction | A, B, C, D | — | — |
| 3BLH | Crystal Structure of Human CDK9/cyclinT1 | x-ray diffraction | B | — | — |
| 3BLH | Crystal structure of human CDK9/CYCLINT1 | x-ray diffraction | B | — | — |
| 3BLQ | Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP | x-ray diffraction | B | — | — |
| 3BLQ | Crystal structure of human CDK9/CYCLINT1 in complex with ATP | x-ray diffraction | B | — | — |
| 3BLR | Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol | x-ray diffraction | B | — | — |
| 3BLR | Crystal structure of human CDK9/CYCLINT1 in complex with flavopiridol | x-ray diffraction | B | — | — |
| 3LQ5 | Structure of CDK9/CyclinT in complex with S-CR8 | x-ray diffraction | B | — | — |
| 3LQ5 | Structure of CDK9/CYCLINT in complex with S-CR8 | x-ray diffraction | B | — | — |
| 3MI9 | Crystal structure of HIV-1 Tat complexed with human P-TEFb | x-ray diffraction | B | — | — |
| 3MI9 | Crystal structure of HIV-1 tat complexed with human P-tefb | x-ray diffraction | B | — | — |
| 3MIA | Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb | x-ray diffraction | B | — | — |
| 3MIA | Crystal structure of HIV-1 tat complexed with ATP-bound human P-tefb | x-ray diffraction | B | — | — |
| 3MY1 | Structure of CDK9/cyclinT1 in complex with DRB | x-ray diffraction | B | — | — |
| 3MY1 | Structure of CDK9/CYCLINT1 in complex with drb | x-ray diffraction | B | — | — |
| 3TN8 | CDK9/cyclin T in complex with CAN508 | x-ray diffraction | B | — | — |
| 3TN8 | CDK9/CYCLIN T in complex with CAN508 | x-ray diffraction | B | — | — |
| 3TNH | CDK9/cyclin T in complex with CAN508 | x-ray diffraction | B | — | — |
| 3TNH | CDK9/CYCLIN T in complex with CAN508 | x-ray diffraction | B | — | — |
| 3TNI | structure of CDK9/cyclin T F241L | x-ray diffraction | B | — | — |
| 3TNI | Structure of CDK9/CYCLIN T F241L | x-ray diffraction | B | — | — |
| 4BCF | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCF | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCG | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCG | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCH | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCH | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCI | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCI | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCJ | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4BCJ | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | x-ray diffraction | B | — | — |
| 4EC8 | Structure of full length CDK9 in complex with cyclinT and DRB | x-ray diffraction | B | — | — |
| 4EC8 | Structure of full length CDK9 in complex with cyclint and drb | x-ray diffraction | B | — | — |
| 4EC9 | Crystal structure of full-length cdk9 in complex with cyclin t | x-ray diffraction | B | — | — |
| 4EC9 | Crystal structure of full-length CDK9 in complex with cyclin T | x-ray diffraction | B | — | — |
| 4IMY | The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat | x-ray diffraction | B, D, F | — | — |
| 4IMY | The AFF4 scaffold binds human P-tefb adjacent to HIV tat | x-ray diffraction | B, D, F | — | — |
| 4OGR | crystal structure of P-TEFb complex with AFF4 and Tat | x-ray diffraction | B, F, K | — | — |
| 4OGR | Crystal structure of P-tefb complex with AFF4 and tat | x-ray diffraction | B, F, K | — | — |
| 4OR5 | Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 | x-ray diffraction | B, G | — | — |
| 4OR5 | Crystal structure of HIV-1 tat complexed with human P-tefb and AFF4 | x-ray diffraction | B, G | — | — |
| 5L1Z | Tar complex with HIV-1 tat-AFF4-P-tefb | x-ray diffraction | B | ACE, ZN | — |
| 6CYT | HIV-1 tar loop in complex with TAT:AFF4:P-tefb | x-ray diffraction | B | ACE, ZN | — |
| 6GZH | Crystal Structure of Human CDK9/cyclinT1 with A86 | x-ray diffraction | B | — | — |
| 6GZH | Crystal structure of human CDK9/CYCLINT1 with A86 | x-ray diffraction | B | — | — |
| 6W9E | Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295 | x-ray diffraction | B | PO4 | 7 (best 0.59) |
| 6W9E | Crystal structure of human CDK9/CYCLINT1 in complex with MC180295 | x-ray diffraction | B | PO4 | — |
| 6Z45 | CDK9-cyclin-T1 complex bound by compound 24 | x-ray diffraction | B | PO4 | — |
| 7NWK | Crystal structure of CDK9-cyclin T1 bound by compound 6 | x-ray diffraction | B | — | — |
| 8K5R | CDK9/cyclin T1 in complex with KB-0742 | x-ray diffraction | B | — | 6 (best 0.53) |
| O60563 | AlphaFold monomer V2.0 prediction for cyclin-T1 (O60563) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4BCG chain B against the predicted model O60563: TM-score 0.99, RMSD 0.73 Å
- 4BCG chain B against the predicted model O60563: TM-score 0.99, RMSD 0.73 Å
- 8K5R chain B against the predicted model O60563: TM-score 0.99, RMSD 0.73 Å
- 4BCF chain B against the predicted model O60563: TM-score 0.99, RMSD 0.74 Å
- 4BCF chain B against the predicted model O60563: TM-score 0.99, RMSD 0.74 Å
- 7NWK chain B against the predicted model O60563: TM-score 0.99, RMSD 0.75 Å
- 3BLQ chain B against the predicted model O60563: TM-score 0.99, RMSD 0.75 Å
- 3BLQ chain B against the predicted model O60563: TM-score 0.99, RMSD 0.75 Å
- 6GZH chain B against the predicted model O60563: TM-score 0.99, RMSD 0.77 Å
- 6GZH chain B against the predicted model O60563: TM-score 0.99, RMSD 0.77 Å
Elsewhere
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