UniProt O59245
tRNA-splicing ligase RtcB (O59245)
tRNA-splicing ligase RtcB (UniProt O59245), EC 6.5.1.8: 19 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O59245
- Protein
- tRNA-splicing ligase RtcB
- EC
- 6.5.1.8
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 29 · 6 records with a druggable one
Structures
20 records of O59245 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UC2 | Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii | x-ray diffraction | A, B | — | — |
| 1UC2 | Hypothetical extein protein of PH1602 from pyrococcus horikoshii | x-ray diffraction | A, B | — | — |
| 4DWQ | RNA ligase RtcB-GMP/Mn(2+) complex | x-ray diffraction | A, B | — | — |
| 4DWQ | RNA ligase rtcb-GMP/MN(2+) complex | x-ray diffraction | A, B | — | — |
| 4DWR | RNA ligase RtcB/Mn2+ complex | x-ray diffraction | B, A, C | — | — |
| 4DWR | RNA ligase RTCB/MN2+ complex | x-ray diffraction | B, A, C | — | — |
| 4ISJ | RNA Ligase RtcB in complex with Mn(II) | x-ray diffraction | A, B | — | — |
| 4ISJ | RNA ligase rtcb in complex with MN(II) | x-ray diffraction | A, B | — | — |
| 4ISZ | RNA ligase RtcB in complex with GTP alphaS and Mn(II) | x-ray diffraction | A, B | — | — |
| 4ISZ | RNA ligase rtcb in complex with GTP alphas and MN(II) | x-ray diffraction | A, B | — | — |
| 4IT0 | Structure of the RNA ligase RtcB-GMP/Mn(II) complex | x-ray diffraction | A, B | — | — |
| 4IT0 | Structure of the RNA ligase rtcb-GMP/MN(II) complex | x-ray diffraction | A, B | — | — |
| 7LFQ | Pyrococcus RNA ligase | x-ray diffraction | A | SO4, K | — |
| 7LFQ | Pyrococcus RNA ligase | x-ray diffraction | A | SO4, K | — |
| 8DC9 | RNA ligase RtcB from Pyrococcus horikoshii in complex with Mn2+ and GTP | x-ray diffraction | A, B | GLC, FRU, GTP, SO4, MN, CL | 4 (best 0.80) |
| 8DCA | RNA ligase RtcB from Pyrococcus horikoshii in complex with Co2+ and GTP | x-ray diffraction | A, B | GLC, FRU, GTP, SO4, CO | 5 (best 0.80) |
| 8DCB | RNA ligase RtcB from Pyrococcus horikoshii in complex with Ni2+ and GTP | x-ray diffraction | A, B | GLC, FRU, GTP, NI, SO4, CL | 4 (best 0.82) |
| 8DCD | RNA ligase RtcB from Pyrococcus horikoshii in complex with Zn2+ and GTP | x-ray diffraction | A, B | GLC, FRU, GTP, SO4, ZN, CL | 3 (best 0.85) |
| 8DCF | RNA ligase RtcB from Pyrococcus horikoshii in complex with Cu2+ and GTP | x-ray diffraction | A, B | GLC, FRU, GTP, SO4, CU, CL | 5 (best 0.80) |
| O59245 | AlphaFold monomer V2.0 prediction for RNA-splicing ligase rtcb (O59245) | predicted | A | — | 8 (best 0.79) |
Ligands
- SO4 · Sulfate ion · in 7 records
- FRU · beta-D-fructofuranose · in 5 records
- GLC · alpha-D-glucopyranose · in 5 records
- GTP · Guanosine-5'-triphosphate · in 5 records
- CL · Chloride ion · in 4 records
- K · Potassium ion · in 2 records
- CO · Cobalt (II) ion · in 1 record
- CU · Copper (II) ion · in 1 record
- MN · Manganese (II) ion · in 1 record
- NI · Nickel (II) ion · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 8DCF chain A against the predicted model O59245: TM-score 0.99, RMSD 1.07 Å
- 8DC9 chain A against the predicted model O59245: TM-score 0.99, RMSD 1.09 Å
- 8DCB chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4ISZ chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4ISZ chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4IT0 chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4IT0 chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4DWQ chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4DWQ chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
- 4ISJ chain A against the predicted model O59245: TM-score 0.99, RMSD 1.10 Å
Elsewhere
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