UniProt O43924
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (O43924)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (UniProt O43924): 49 experimental structures on GenesisL1, 16 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in…
- UniProt
- O43924
- Protein
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit…
- Experimental structures
- 49
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 3 · 3 records with a druggable one
Structures
49 records of O43924 in the MolNFT archive: 49 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KSG | Complex of Arl2 and PDE delta, Crystal Form 1 | x-ray diffraction | B | — | — |
| 1KSG | Complex of ARL2 and pde delta, crystal form 1 | x-ray diffraction | B | — | — |
| 1KSH | Complex of Arl2 and PDE delta, Crystal Form 2 (native) | x-ray diffraction | B | — | — |
| 1KSH | Complex of ARL2 and pde delta, crystal form 2 (native) | x-ray diffraction | B | — | — |
| 1KSJ | Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet) | x-ray diffraction | B | — | — |
| 1KSJ | Complex of ARL2 and pde delta, crystal form 2 (semet) | x-ray diffraction | B | — | — |
| 3T5G | Structure of fully modified farnesylated Rheb in complex with PDE6D | x-ray diffraction | B | — | — |
| 3T5G | Structure of fully modified farnesylated rheb in complex with PDE6D | x-ray diffraction | B | — | — |
| 3T5I | Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D | x-ray diffraction | B, A, C, D | — | — |
| 3T5I | Structure of fully modified farnesylated rheb peptide in complex with PDE6D | x-ray diffraction | B, A, C, D | — | — |
| 4JHP | The crystal structure of the RPGR RCC1-like domain in complex with PDE6D | x-ray diffraction | B | — | — |
| 4JHP | The crystal structure of the rpgr RCC1-like domain in complex with PDE6D | x-ray diffraction | B | — | — |
| 4JV6 | The crystal structure of PDE6D in complex to inhibitor-1 | x-ray diffraction | B | — | — |
| 4JV6 | The crystal structure of PDE6D in complex to inhibitor-1 | x-ray diffraction | B | — | — |
| 4JV8 | The crystal structure of PDE6D in complex with rac-S1 | x-ray diffraction | B | — | — |
| 4JV8 | The crystal structure of PDE6D in complex with rac-S1 | x-ray diffraction | B | — | — |
| 4JVB | Crystal structure of PDE6D in complex with the inhibitor rac-2 | x-ray diffraction | B | — | — |
| 4JVB | Crystal structure of PDE6D in complex with the inhibitor rac-2 | x-ray diffraction | B | — | — |
| 4JVF | The Crystal structure of PDE6D in complex with the inhibitor (s)-5 | x-ray diffraction | B | — | — |
| 4JVF | The crystal structure of PDE6D in complex with the inhibitor (S)-5 | x-ray diffraction | B | — | — |
| 5E80 | The crystal structure of PDEd in complex with inhibitor-2a | x-ray diffraction | B, A | 5KP | — |
| 5E80 | The crystal structure of pded in complex with inhibitor-2A | x-ray diffraction | B, A | — | — |
| 5E8F | Structure of fully modified geranylgeranylated PDE6C peptide in complex with PDE6D | x-ray diffraction | A, C | — | — |
| 5F2U | Structure of fully modified farnesylated INPP5E peptide in complex with PDE6D | x-ray diffraction | A, B | — | — |
| 5ML2 | The crystal structure of PDE6D in complex with inhibitor-3 | x-ray diffraction | B | NH6 | — |
| 5ML2 | The crystal structure of PDE6D in complex with inhibitor-3 | x-ray diffraction | B | NH6 | — |
| 5ML3 | The crystal structure of PDE6D in complex to DELTASONAMIDE1 | x-ray diffraction | B | — | — |
| 5ML4 | The crystal structure of PDE6D in complex to inhibitor-7 | x-ray diffraction | B | RRQ | — |
| 5ML4 | The crystal structure of PDE6D in complex to inhibitor-7 | x-ray diffraction | B | RRQ | — |
| 5ML6 | The crystal structure of PDE6D in complex to inhibitor-8 | x-ray diffraction | B | — | — |
| 5ML8 | The crystal structure of PDE6D in complex to inhibitor-4 | x-ray diffraction | B | V98 | — |
| 5ML8 | The crystal structure of PDE6D in complex to inhibitor-4 | x-ray diffraction | B | — | — |
| 5NAL | The crystal structure of inhibitor-15 covalently bound to PDE6D | x-ray diffraction | B | 8RQ | — |
| 5TAR | Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II… | x-ray diffraction | B | FAR | 1 (best 0.83) |
| 5TAR | Crystal structure of farnesylated and methylated KRAS4B in complex with pde-delta (crystal form II… | x-ray diffraction | B | FAR | — |
| 5TB5 | Crystal structure of full-length farnesylated and methylated KRAS4B in complex with pde-delta… | x-ray diffraction | B, D | FAR | — |
| 5X72 | The crystal structure pde delta in complex with (rac)-P9 | x-ray diffraction | A | P59, P69 | — |
| 5X73 | The crystal structure pde delta in complex with R-P9 | x-ray diffraction | A | P59 | — |
| 5X74 | The crystal structure pde delta in complex with compound (R, R)-1G | x-ray diffraction | A | JAY | — |
| 5YAV | Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction | x-ray diffraction | B | 8SF | 1 (best 0.83) |
| 5YAV | Fragment-based drug discovery of inhibitors to block pdedelta-RAS protein-protein interaction | x-ray diffraction | B | 8SF | — |
| 5YAW | Fragment-based drug discovery of inhibitors to block pdedelta-RAS protein-protein interaction | x-ray diffraction | B | 8SL | — |
| 7PAC | The crystal structure of PDE6D in the apo state | x-ray diffraction | B | NI | — |
| 7PAD | The crystal structure of dw-0254 in complex with PDE6D | x-ray diffraction | B | NI, O7W | — |
| 7PAE | The crystal structure of Deltarasin in complex with PDE6D | x-ray diffraction | B | O7T | 1 (best 0.83) |
| 7PAE | The crystal structure of deltarasin in complex with PDE6D | x-ray diffraction | B | O7T | — |
| 7Q9Q | Crystal structure of PDE6D Geranylgeranylated cystein complex | x-ray diffraction | BBB | GER | — |
| 7Q9U | Crystal structure of the high affinity KRas mutant PDE6D complex | x-ray diffraction | DDD, CCC | FAR, SO4 | — |
| O43924 | AlphaFold monomer V2.0 prediction for retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic… | — | — | — |
Ligands
- FAR · Farnesyl · in 4 records
- 8SF · 1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole · in 2 records
- NH6 · ~{N}1-[(4-chlorophenyl)methyl]-~{N}1-cyclopentyl-~{N}4-(phenylmethyl)benzene-1,4-disulfonamide · in 2 records
- NI · Nickel (II) ion · in 2 records
- O7T · deltarasin · in 2 records
- P59 · (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one · in 2 records
- RRQ · 4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl) amino]methyl]-2-(methylamino)benzoic acid · in 2 records
- 5KP · N-(3-chloro-2-methylphenyl)-4-(3,4-dimethyl-7-oxo-2-phenyl-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide · in 1 record
- 8RQ · ~{N}4-[(4-chlorophenyl)methyl]-~{N}1-(cyclohexylmethyl)-~{N}4-cyclopentyl-~{N}1-[(~{Z})-4-[(~{E})-methyliminomethyl]-5-oxidanyl-hex-4-enyl]benzene-1,4-disulfonamide · in 1 record
- 8SL · 3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-methylpropyl)-4-(phenylmethyl)-1,2,4-triazole · in 1 record
- GER · Geran-8-yl geran · in 1 record
- JAY · (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one · in 1 record
- O7W · ~{N}-[(4-ethylphenyl)methyl]-3-[5-[2-(1~{H}-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-yl]-~{N}-methyl-propanamide · in 1 record
- P69 · (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one · in 1 record
- SO4 · Sulfate ion · in 1 record
- V98 · ~{N}4-[(4-chlorophenyl)methyl]-~{N}4-cyclopentyl-~{N}1-(phenylmethyl)-~{N}1-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide · in 1 record
Elsewhere
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