UniProt O19069
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (O19069)
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (UniProt O19069), EC 6.2.1.4, 6.2.1.5: 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 9 pockets. Binding sites, druggability…
- UniProt
- O19069
- Protein
- Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
- EC
- 6.2.1.4, 6.2.1.5
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 9 · 2 records with a druggable one
Structures
17 records of O19069 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EUC | Crystal structure of dephosphorylated pig heart, GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | — | — |
| 1EUC | Crystal structure of dephosphorylated pig heart, GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | — | — |
| 2FP4 | Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP | x-ray diffraction | — | — | |
| 2FPG | Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GDP | x-ray diffraction | — | — | |
| 2FPI | Crystal structure of pig GTP-specific succinyl-CoA synthetase from polyethylene glycol | x-ray diffraction | — | — | |
| 2FPP | Crystal structure of pig GTP-specific succinyl-CoA synthetase from polyethylene glycol with… | x-ray diffraction | — | — | |
| 4XX0 | CoA bound to pig GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | — | — |
| 4XX0 | CoA bound to pig GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | — | — |
| 5CAE | Succinate bound to pig GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | — | — |
| 6XRU | GTP-specific succinyl-CoA synthetase complexed with desulfo-coenzyme A, magnesium ions and… | x-ray diffraction | A | DCA, PO4, MG | 3 (best 0.81) |
| 6XRU | GTP-specific succinyl-CoA synthetase complexed with desulfo-coenzyme a, magnesium ions and… | x-ray diffraction | A | DCA, PO4 | — |
| 7JFP | GTP-specific succinyl-CoA synthetase complexed with Mg-GDP, phosphohistidine loop pointing towards… | x-ray diffraction | A | GDP, MG | 4 (best 0.76) |
| 7JFP | GTP-specific succinyl-CoA synthetase complexed with mg-GDP, phosphohistidine loop pointing towards… | x-ray diffraction | A | MG | — |
| 7JJ0 | GTP-specific succinyl-CoA synthetase complexed with mg-gmppcp | x-ray diffraction | A, C | GCP | — |
| 7JKR | GTP-specific succinyl-CoA synthetase complexed with mg-gmppnp, phosphohistidine loop pointing… | x-ray diffraction | A | GNP | — |
| 7JMK | GTP-specific succinyl-CoA synthetase complexed with mg-GDP in space group P32 | x-ray diffraction | A, C | — | — |
| O19069 | AlphaFold monomer V2.0 prediction for succinate--CoA ligase [ADP/GDP- forming] subunit alpha… | predicted | A | — | 2 (best 0.43) |
Ligands
Experiment against prediction
- 5CAE chain A against the predicted model O19069: TM-score 1.00, RMSD 0.32 Å
- 1EUC chain A against the predicted model O19069: TM-score 1.00, RMSD 0.39 Å
- 1EUC chain A against the predicted model O19069: TM-score 1.00, RMSD 0.39 Å
- 4XX0 chain A against the predicted model O19069: TM-score 1.00, RMSD 0.38 Å
- 4XX0 chain A against the predicted model O19069: TM-score 1.00, RMSD 0.38 Å
- 6XRU chain A against the predicted model O19069: TM-score 0.98, RMSD 0.37 Å
- 6XRU chain A against the predicted model O19069: TM-score 0.98, RMSD 0.37 Å
- 7JMK chain C against the predicted model O19069: TM-score 0.98, RMSD 1.08 Å
- 7JJ0 chain C against the predicted model O19069: TM-score 0.98, RMSD 1.15 Å
- 7JJ0 chain A against the predicted model O19069: TM-score 0.98, RMSD 1.47 Å
Elsewhere
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