UniProt O15648
ATP-dependent 6-phosphofructokinase (O15648)
ATP-dependent 6-phosphofructokinase (UniProt O15648), EC 2.7.1.11: 13 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O15648
- Protein
- ATP-dependent 6-phosphofructokinase
- EC
- 2.7.1.11
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 67 · 4 records with a druggable one
Structures
14 records of O15648 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HIG | Crystal Structure of Phosphofructokinase apoenzyme from Trypanosoma brucei. | x-ray diffraction | A, B | — | — |
| 2HIG | Crystal structure of phosphofructokinase apoenzyme from trypanosoma brucei. | x-ray diffraction | A, B | — | — |
| 3CVL | Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5… | x-ray diffraction | B | — | — |
| 3CVL | Structure of peroxisomal targeting signal 1 (PTS1) binding domain of trypanosoma brucei peroxin 5… | x-ray diffraction | B | — | — |
| 3F5M | Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei | x-ray diffraction | A, B, C, D | — | — |
| 3F5M | Crystal structure of ATP-bound phosphofructokinase from trypanosoma brucei | x-ray diffraction | A, B, C, D | — | — |
| 6QU3 | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D | JJ5, SEP | 20 (best 0.83) |
| 6QU3 | Crystal structure of phosphofructokinase from trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D | JJ5 | — |
| 6QU4 | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D | JJ2 | 20 (best 0.82) |
| 6QU4 | Crystal structure of phosphofructokinase from trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D | JJ2 | — |
| 6QU5 | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D, E, F, G, H | JJ8 | 20 (best 0.85) |
| 6QU5 | Crystal structure of phosphofructokinase from trypanosoma brucei in complex with an allosteric… | x-ray diffraction | A, B, C, D, E, F, G, H | JJ8 | — |
| 6SY7 | Structure of trypanosome brucei phosphofructokinase in complex with AMP. | x-ray diffraction | A, B, C, D, E, F, G, H | BNZ, AMP | — |
| O15648 | AlphaFold monomer V2.0 prediction for ATP-dependent 6-phosphofructokinase (O15648) | predicted | A | — | 7 (best 0.71) |
Ligands
- JJ2 · 1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino) ethyl]pyrrolo[3,2-c]pyridin-4-one · in 2 records
- JJ5 · 1-[(3,4-dichlorophenyl)methyl]-7~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- JJ8 · 1-[(3,4-dichlorophenyl)methyl]imidazole · in 2 records
- AMP · Adenosine monophosphate · in 1 record
- BNZ · Benzene · in 1 record
- SEP · Phosphoserine · in 1 record
Experiment against prediction
- 2HIG chain B against the predicted model O15648: TM-score 0.97, RMSD 1.47 Å
- 2HIG chain B against the predicted model O15648: TM-score 0.97, RMSD 1.47 Å
- 2HIG chain A against the predicted model O15648: TM-score 0.95, RMSD 1.96 Å
- 2HIG chain A against the predicted model O15648: TM-score 0.95, RMSD 1.96 Å
- 6QU4 chain D against the predicted model O15648: TM-score 0.93, RMSD 1.54 Å
- 6QU4 chain D against the predicted model O15648: TM-score 0.93, RMSD 1.54 Å
- 6QU3 chain B against the predicted model O15648: TM-score 0.93, RMSD 1.34 Å
- 6QU3 chain B against the predicted model O15648: TM-score 0.93, RMSD 1.34 Å
- 6QU4 chain A against the predicted model O15648: TM-score 0.93, RMSD 1.48 Å
- 6QU4 chain A against the predicted model O15648: TM-score 0.93, RMSD 1.48 Å
Elsewhere
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