MolNFT v1 · #161952 · protein
Crystal structure of phosphofructokinase from trypanosoma brucei in complex with an allosteric inhibitor CTCB12
6QU5: “Crystal structure of phosphofructokinase from trypanosoma brucei in complex with an allosteric inhibitor…”. X-ray diffraction, 1 ligand (JJ8). MolNFT v1 #161952 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QU5
- Type
- protein
- Length
- 3,645 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O15648
- Ligands
- JJ8
Structure
x-ray diffraction · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 452 | — | O15648 |
| B | — | protein | 459 | — | O15648 |
| C | — | protein | 461 | — | O15648 |
| D | — | protein | 453 | — | O15648 |
| E | — | protein | 456 | — | O15648 |
| F | — | protein | 456 | — | O15648 |
| G | — | protein | 455 | — | O15648 |
| H | — | protein | 453 | — | O15648 |
Ligands and binding sites
- JJ8 · 1-[(3,4-dichlorophenyl)methyl]imidazole · ligand · 2 copies · chains A, B
- CIT · Citric acid · additive · 8 copies · chains A, B, C, D, E, F, G, H
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6QU5 · Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an… · the same entry in another collection · chain H against H, TM-score 1.00
- O15648 · AlphaFold monomer V2.0 prediction for ATP-dependent 6-phosphofructokinase (O15648) · a predicted model of the same protein · chain G against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15648
- Elsewhere: RCSB PDB 6QU5 · PDBe 6QU5 · UniProt O15648
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