UniProt O15519
CASP8 and FADD-like apoptosis regulator subunit p43 (O15519)
CASP8 and FADD-like apoptosis regulator subunit p43 (UniProt O15519): 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 131 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O15519
- Protein
- CASP8 and FADD-like apoptosis regulator subunit p43
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 131 · 8 records with a druggable one
Structures
18 records of O15519 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N5R | NMR structure of cFLIP-derived calmodulin binding peptide | solution nmr | A | — | — |
| 2N5R | NMR structure of cflip-derived calmodulin binding peptide | solution nmr | A | — | — |
| 3H11 | Zymogen caspase-8:c-FLIPL protease domain complex | x-ray diffraction | A | — | — |
| 3H11 | Zymogen caspase-8:C-flipl protease domain complex | x-ray diffraction | A | — | — |
| 3H13 | c-FLIPL protease-like domain | x-ray diffraction | A | — | — |
| 3H13 | C-flipl protease-like domain | x-ray diffraction | A | — | — |
| 6M6O | NMR solution structure of a C-flips | solution nmr | A | — | — |
| 7DEE | Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8 | solution nmr | A | — | 2 (best 0.48) |
| 7DEE | Structural basis of the regulation of disc assembly by the interaction of C-flips with procaspase-8 | solution nmr | A | — | — |
| 8YBX | Structure of the FADD/Caspase-8/cFLIP death effector domain assembly | electron microscopy | H, I, J, K | — | 17 (best 0.76) |
| 8YD7 | Structure of FADD/Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | G, H, I, K | SE | 10 (best 0.79) |
| 8YD8 | Structure of FADD/Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | I, H, J, K | — | 14 (best 0.83) |
| 8YM6 | Structure of Caspase-8/cFLIP death effector domain assembly | x-ray diffraction | H, G, F, K, I, J, M, O, N | — | 18 (best 0.80) |
| 8YNI | Structure of the FADD/Caspase-8/cFLIP death effector domain assembly | electron microscopy | H, I, J, K, G | — | 18 (best 0.77) |
| 8YNL | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | H, I, J, K, G, F | — | 19 (best 0.74) |
| 8YNM | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | O, H, I, J, K, G, F, N | — | 18 (best 0.76) |
| 8YNN | Structure of the Caspase-8/cFLIP death effector domain assembly | electron microscopy | H, I, J, K | — | 15 (best 0.75) |
| O15519 | AlphaFold monomer V2.0 prediction for CASP8 and fadd-like apoptosis regulator (O15519) | predicted | A | — | — |
Ligands
- SE · Selenium atom · in 1 record
Experiment against prediction
- 3H13 chain A against the predicted model O15519: TM-score 0.99, RMSD 0.41 Å
- 3H13 chain A against the predicted model O15519: TM-score 0.99, RMSD 0.41 Å
- 8YM6 chain M against the predicted model O15519: TM-score 0.98, RMSD 0.64 Å
- 8YD8 chain H against the predicted model O15519: TM-score 0.98, RMSD 0.70 Å
- 8YD8 chain J against the predicted model O15519: TM-score 0.98, RMSD 0.74 Å
- 3H11 chain A against the predicted model O15519: TM-score 0.98, RMSD 1.04 Å
- 3H11 chain A against the predicted model O15519: TM-score 0.98, RMSD 1.04 Å
- 8YD7 chain K against the predicted model O15519: TM-score 0.98, RMSD 0.77 Å
- 8YM6 chain N against the predicted model O15519: TM-score 0.98, RMSD 0.82 Å
- 8YM6 chain J against the predicted model O15519: TM-score 0.98, RMSD 0.79 Å
Elsewhere
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