MolNFT v1 · #156515 · protein

NMR solution structure of a C-flips

6M6O · CASP8 and fadd-like apoptosis regulator: “NMR solution structure of a C-flips”. Solution nmr, 2 pockets (best druggability 0.44). MolNFT v1 #156515 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6M6O
Type: protein
Length: 185 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CASP8 and fadd-like apoptosis regulator
UniProt: O15519
Pockets: 2 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 61% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CASP8 and fadd-like apoptosis regulator	protein	185	61% helix, 1% strand	O15519

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.44	0.76	23	empty
2	78	0.35	0.75	15	empty

Compared structures

6M6O · NMR SOLUTION STRUCTURE OF A C-FLIPs · the same entry in another collection · chain A against A, TM-score 1.00
O15519 · AlphaFold monomer V2.0 prediction for CASP8 and fadd-like apoptosis regulator (O15519) · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15519
Elsewhere: RCSB PDB 6M6O · PDBe 6M6O · UniProt O15519

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