MolNFT v1 · #176193 · protein

Structural basis of the regulation of disc assembly by the interaction of C-flips with procaspase-8

7DEE · CASP8 and fadd-like apoptosis regulator: “Structural basis of the regulation of disc assembly by the interaction of C-flips with procaspase-8”. Solution nmr, 2 pockets (best druggability 0.48). MolNFT v1 #176193 on GenesisL1: 3D…

PDB: 7DEE
Type: protein
Length: 193 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CASP8 and fadd-like apoptosis regulator; C8-H1A
UniProt: O15519
Pockets: 2 · best druggability 0.48

Structure

solution nmr · 2 distinct chains · 60% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CASP8 and fadd-like apoptosis regulator	protein	185	63% helix, 1% strand	O15519
B	C8-H1A	protein	8	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.48	0.77	24	empty
2	104	0.42	0.78	21	empty

Interfaces

1 interface between chains.

A–B · 470 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7DEE · Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with… · the same entry in another collection · chain A against A, TM-score 1.00
O15519 · AlphaFold monomer V2.0 prediction for CASP8 and fadd-like apoptosis regulator (O15519) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15519
Elsewhere: RCSB PDB 7DEE · PDBe 7DEE · UniProt O15519

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