UniProt O15439
ATP-binding cassette sub-family C member 4 (O15439)
ATP-binding cassette sub-family C member 4 (UniProt O15439), EC 7.6.2.-, 7.6.2.2: 15 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 292 pockets. Binding sites, druggability and experiment against…
- UniProt
- O15439
- Protein
- ATP-binding cassette sub-family C member 4
- EC
- 7.6.2.-, 7.6.2.2, 7.6.2.3
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 292 · 16 records with a druggable one
Structures
16 records of O15439 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8BWP | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with methotrexate) | electron microscopy | A | MTX | 16 (best 0.82) |
| 8BWQ | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with topotecan) | electron microscopy | A | TTC | 19 (best 0.83) |
| 8BWR | Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with prostaglandin E2) | electron microscopy | A | P2E | 20 (best 0.81) |
| 8I4A | Cryo-EM structure of dipyridamole-bound ABCC4 | electron microscopy | A | H9F | 20 (best 0.83) |
| 8I4B | Cryo-EM structure of apo-form ABCC4 | electron microscopy | A | — | 17 (best 0.83) |
| 8I4C | Cryo-EM structure of U46619-bound ABCC4 | electron microscopy | A | PUC | 16 (best 0.84) |
| 8IZ7 | cryo-EM structure of sulindac-bound hMRP4 | electron microscopy | A | SUZ | 20 (best 0.83) |
| 8IZ8 | cryo EM structure of apo hMRP4 | electron microscopy | A | — | 19 (best 0.84) |
| 8IZ9 | cryo-EM structure of PGE1-bound hMRP4 | electron microscopy | A | XPG | 20 (best 0.82) |
| 8IZA | cryo-EM structure of ATP-bound hMRP4 | electron microscopy | A | ATP, MG | 19 (best 0.90) |
| 8J3W | Cryo-EM structure of aspirin-bound ABCC4 | electron microscopy | A | AIN | 18 (best 0.82) |
| 8J3Z | Cryo-EM structure of ATP-U46619-bound ABCC4 | electron microscopy | A | ATP, MG, PUC | 18 (best 0.89) |
| 8XOK | Cryo-EM structure of human ABCC4 | electron microscopy | A | DU0, PLM | 18 (best 0.84) |
| 8XOL | Cryo-EM structure of human ABCC4 with ANP bound in NBD1 | electron microscopy | A | ANP, DU0, PLM, MG | 16 (best 0.84) |
| 8XOM | Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE | electron microscopy | A | ANP, MTX, DU0, PLM, MG | 18 (best 0.84) |
| O15439 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 4 (O15439) | predicted | A | — | 18 (best 0.83) |
Ligands
- MG · Magnesium ion · in 4 records
- DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol · in 3 records
- PLM · Palmitic acid · in 3 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MTX · Methotrexate · in 2 records
- PUC · (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid · in 2 records
- AIN · 2-(acetyloxy)benzoic acid · in 1 record
- H9F · 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl) amino]ethanol · in 1 record
- P2E · (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid · in 1 record
- SUZ · [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid · in 1 record
- TTC · (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]inolizino[1,2-B]-quinoline-3, 14(4H,12H)-dione · in 1 record
- XPG · 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid · in 1 record
Experiment against prediction
- 8IZ8 chain A against the predicted model O15439: TM-score 0.94, RMSD 3.12 Å
- 8IZ9 chain A against the predicted model O15439: TM-score 0.94, RMSD 3.16 Å
- 8XOK chain A against the predicted model O15439: TM-score 0.92, RMSD 3.66 Å
- 8BWP chain A against the predicted model O15439: TM-score 0.91, RMSD 3.51 Å
- 8BWQ chain A against the predicted model O15439: TM-score 0.91, RMSD 3.66 Å
- 8XOL chain A against the predicted model O15439: TM-score 0.91, RMSD 3.64 Å
- 8BWR chain A against the predicted model O15439: TM-score 0.91, RMSD 3.77 Å
- 8XOM chain A against the predicted model O15439: TM-score 0.91, RMSD 3.73 Å
- 8I4C chain A against the predicted model O15439: TM-score 0.90, RMSD 3.91 Å
- 8I4A chain A against the predicted model O15439: TM-score 0.90, RMSD 3.95 Å
Elsewhere
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