UniProt O14807
Ras-related protein M-Ras (O14807)
Ras-related protein M-Ras (UniProt O14807), EC 3.6.5.2: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14807
- Protein
- Ras-related protein M-Ras
- EC
- 3.6.5.2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 42 · 7 records with a druggable one
Structures
11 records of O14807 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7SD0 | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | electron microscopy | B | GCP, MG | 5 (best 0.85) |
| 7SD0 | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | electron microscopy | B | GCP, MG | — |
| 7TVF | Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom | x-ray diffraction | E, B | GNP, SO4, MG, NA | 12 (best 0.87) |
| 7TVF | Crystal structure of the SHOC2-mras-PP1CA (smp) complex to a resolution of 2.17 ångström | x-ray diffraction | E, B | GNP, SO4, MG, NA | — |
| 7TXH | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | x-ray diffraction | A, D | GNP, MG | 13 (best 0.85) |
| 7TXH | Human mras Q71R in complex with human SHOC2 lrr domain M173I and human PP1CA | x-ray diffraction | A, D | GNP, MG | — |
| 7UPI | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | electron microscopy | A | GTP, MG | 5 (best 0.86) |
| 7UPI | Cryo-EM structure of SHOC2-PP1C-mras holophosphatase complex | electron microscopy | A | GTP, MG | — |
| 9C1A | Crystal structure of GDP-bound human M-RAS protein in crystal form I | x-ray diffraction | A | MG, GDP | 1 (best 0.55) |
| 9C1B | Crystal structure of GDP-bound human M-RAS protein in crystal form II | x-ray diffraction | A, B, C, D | MG, GDP | 4 (best 0.73) |
| O14807 | AlphaFold monomer V2.0 prediction for RAS-related protein M-RAS (O14807) | predicted | A | — | 2 (best 0.50) |
Ligands
- MG · Magnesium ion · in 10 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 4 records
- GCP · Phosphomethylphosphonic acid guanylate ester · in 2 records
- GDP · Guanosine-5'-diphosphate · in 2 records
- GTP · Guanosine-5'-triphosphate · in 2 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 7UPI chain A against the predicted model O14807: TM-score 0.98, RMSD 0.81 Å
- 7UPI chain A against the predicted model O14807: TM-score 0.98, RMSD 0.81 Å
- 7TXH chain D against the predicted model O14807: TM-score 0.98, RMSD 0.80 Å
- 7TXH chain D against the predicted model O14807: TM-score 0.98, RMSD 0.80 Å
- 7TXH chain A against the predicted model O14807: TM-score 0.98, RMSD 0.84 Å
- 7TXH chain A against the predicted model O14807: TM-score 0.98, RMSD 0.84 Å
- 7TVF chain E against the predicted model O14807: TM-score 0.98, RMSD 1.00 Å
- 7TVF chain E against the predicted model O14807: TM-score 0.98, RMSD 1.00 Å
- 7TVF chain B against the predicted model O14807: TM-score 0.98, RMSD 0.88 Å
- 7TVF chain B against the predicted model O14807: TM-score 0.98, RMSD 0.88 Å
Elsewhere
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