UniProt O14786
Neuropilin-1 (O14786)
Neuropilin-1 (UniProt O14786): 35 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14786
- Protein
- Neuropilin-1
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 19 · 4 records with a druggable one
Structures
36 records of O14786 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KEX | Crystal Structure of the b1 Domain of Human Neuropilin-1 | x-ray diffraction | A | — | — |
| 1KEX | Crystal structure of the B1 domain of human neuropilin-1 | x-ray diffraction | A | — | — |
| 2QQI | Crystal Structure of the b1b2 Domains from Human Neuropilin-1 | x-ray diffraction | A | — | — |
| 2QQI | Crystal structure of the B1B2 domains from human neuropilin-1 | x-ray diffraction | A | — | — |
| 2QQM | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1 | x-ray diffraction | A | — | — |
| 2QQM | Crystal structure of the A2B1B2 domains from human neuropilin-1 | x-ray diffraction | A | — | — |
| 2QQN | Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab | x-ray diffraction | A | — | — |
| 2QQN | Neuropilin-1 B1 domain in complex with a VEGF-blocking Fab | x-ray diffraction | A | — | — |
| 3I97 | B1 domain of human Neuropilin-1 bound with small molecule EG00229 | x-ray diffraction | A, B | — | — |
| 3I97 | B1 domain of human neuropilin-1 bound with small molecule EG00229 | x-ray diffraction | A, B | — | — |
| 4DEQ | Structure of the Neuropilin-1/VEGF-A complex | x-ray diffraction | A, B | — | — |
| 4DEQ | Structure of the neuropilin-1/VEGF-a complex | x-ray diffraction | A, B | — | — |
| 4RN5 | B1 domain of human Neuropilin-1 with acetate ion in a ligand-binding site | x-ray diffraction | A | — | — |
| 4RN5 | B1 domain of human neuropilin-1 with acetate ion in a ligand-binding site | x-ray diffraction | A | — | — |
| 5C7G | Crystal structure of the B1 domain of human neuropilin-1 in complex with a bicine molecule | x-ray diffraction | A | — | — |
| 5IJR | X-ray structure of neuropilin-1 B1 domain complexed with arg-1 ligand. | x-ray diffraction | A, B | — | — |
| 5IYY | X-ray structure of neuropilin-1 B1 domain complexed with arg-4 ligand. | x-ray diffraction | A, B | — | — |
| 5J1X | X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand. | x-ray diffraction | A, B, C, D | AR5 | — |
| 5J1X | X-ray structure of neuropilin-1 B1 domain complexed with arg-5 ligand. | x-ray diffraction | A, B, C, D | — | — |
| 5JGI | X-ray structure of neuropilin-1 B1 domain complexed with M45 compound | x-ray diffraction | A, B | — | — |
| 5JGQ | X-ray structure of neuropilin-1 b1 domain complexed with Arg-7 ligand. | x-ray diffraction | A, B | 6JY | 3 (best 0.41) |
| 5JGQ | X-ray structure of neuropilin-1 B1 domain complexed with arg-7 ligand. | x-ray diffraction | A, B | — | — |
| 5JHK | X-ray structure of neuropilin-1 b1 domain complexed with Arg-6 ligand. | x-ray diffraction | A, B | 6K8 | — |
| 5JHK | X-ray structure of neuropilin-1 B1 domain complexed with arg-6 ligand. | x-ray diffraction | A, B | — | — |
| 5L73 | Mam domain of human neuropilin-1 | x-ray diffraction | A, B | CA, BCN, TAM | — |
| 6FMC | NEUROPILIN1-B1 domain in complex with EG01377, 0.9 ångström structure | x-ray diffraction | A | DUE | — |
| 6FMF | Neuropilin-1 B1 domain in complex with EG01377; 2.8 ångström structure | x-ray diffraction | A | DUE | — |
| 6TKK | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide | x-ray diffraction | A | — | — |
| 6TKK | Neuropilin 1-B1 domain in a complex with the C-terminal VEGFB186 peptide | x-ray diffraction | A | — | — |
| 7JJC | Crystal structure of neuropilin-1 b1 domain in complex with SARS-CoV-2 S1 C-end rule (CendR) peptide | x-ray diffraction | A, B, C, D | — | 5 (best 0.82) |
| 7JJC | Crystal structure of neuropilin-1 B1 domain in complex with SARS-cov-2 S1 C-end rule (cendr) peptide | x-ray diffraction | A, B, C, D | — | — |
| 7O1N | Crystal structure of human neuropilin-1 B1 domain mutant - Y297A | x-ray diffraction | A | — | — |
| 8C5G | Structure of human Neuropilin-1 b1b2 domains in complex with Chlorotoxin (Leiurus quinquestriatus) | x-ray diffraction | A, B | — | — |
| 8PFE | Crystal Structure of an Hexavariant of the b1 Domain of Human Neuropilin-1 in Complex with the… | x-ray diffraction | A, C | — | 1 (best 0.67) |
| 9EOU | Crystal Structure of the b1b2 domains from Human Neuropilin-1 in complex with a peptide. | x-ray diffraction | A | — | 2 (best 0.52) |
| O14786 | AlphaFold monomer V2.0 prediction for neuropilin-1 (O14786) | predicted | A | — | 8 (best 0.69) |
Ligands
- DUE · (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid · in 2 records
- 6JY · N~2~-(benzenecarbonyl)-L-arginine · in 1 record
- 6K8 · N-(benzenecarbonyl)glycyl-L-arginine · in 1 record
- AR5 · N~2~-(tert-butoxycarbonyl)-L-arginine · in 1 record
- BCN · Bicine · in 1 record
- CA · Calcium ion · in 1 record
- TAM · Tris(hydroxyethyl)aminomethane · in 1 record
Experiment against prediction
- 2QQN chain A against the predicted model O14786: TM-score 1.00, RMSD 0.29 Å
- 2QQN chain A against the predicted model O14786: TM-score 1.00, RMSD 0.29 Å
- 8PFE chain A against the predicted model O14786: TM-score 0.99, RMSD 0.38 Å
- 5JGQ chain B against the predicted model O14786: TM-score 0.99, RMSD 0.45 Å
- 5JGQ chain B against the predicted model O14786: TM-score 0.99, RMSD 0.45 Å
- 5JGI chain B against the predicted model O14786: TM-score 0.99, RMSD 0.47 Å
- 5J1X chain B against the predicted model O14786: TM-score 0.99, RMSD 0.48 Å
- 5J1X chain B against the predicted model O14786: TM-score 0.99, RMSD 0.48 Å
- 5JHK chain A against the predicted model O14786: TM-score 0.99, RMSD 0.50 Å
- 5JHK chain A against the predicted model O14786: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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