UniProt O14246
Protection of telomeres protein tpz1 (O14246)
Protection of telomeres protein tpz1 (UniProt O14246): 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14246
- Protein
- Protection of telomeres protein tpz1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 1 record with a druggable one
Structures
15 records of O14246 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WE0 | Structural Basis for Shelterin Bridge Assembly | x-ray diffraction | B, E, H, K | ZN | 2 (best 0.39) |
| 5WE0 | Structural basis for shelterin bridge assembly | x-ray diffraction | B, E, H, K | ZN | — |
| 5WE1 | Structural Basis for Shelterin Bridge Assembly | x-ray diffraction | B, D | ZN | — |
| 5WE1 | Structural basis for shelterin bridge assembly | x-ray diffraction | B, D | ZN | — |
| 5WE2 | Structural Basis for Telomere Length Regulation by the Shelterin Bridge | x-ray diffraction | B, D | ZN | 3 (best 0.49) |
| 5WE2 | Structural basis for telomere length regulation by the shelterin bridge | x-ray diffraction | B, D | ZN | — |
| 5XXE | Crystal structure of Poz1 and Tpz1 | x-ray diffraction | C, D | ZN, SO4 | 3 (best 0.36) |
| 5XXE | Crystal structure of POZ1 and TPZ1 | x-ray diffraction | C, D | ZN, SO4 | — |
| 5XXF | Crystal structure of Poz1, Tpz1 and Rap1 | x-ray diffraction | C, D | ZN | 3 (best 0.39) |
| 5XXF | Crystal structure of POZ1, TPZ1 and RAP1 | x-ray diffraction | C, D | ZN | — |
| 7CUI | Crystal structure of fission yeast Pot1 and Tpz1 | x-ray diffraction | B, D | — | 1 (best 0.26) |
| 7CUI | Crystal structure of fission yeast POT1 and TPZ1 | x-ray diffraction | B, D | — | — |
| 7CUJ | Crystal structure of fission yeast Ccq1 and Tpz1 | x-ray diffraction | C, D | — | 3 (best 0.48) |
| 7CUJ | Crystal structure of fission yeast CCQ1 and TPZ1 | x-ray diffraction | C, D | — | — |
| O14246 | AlphaFold monomer V2.0 prediction for protection of telomeres protein TPZ1 (O14246) | predicted | A | — | 2 (best 0.57) |
Ligands
Experiment against prediction
- 7CUJ chain C against the predicted model O14246: TM-score 0.68, RMSD 1.93 Å
- 7CUJ chain C against the predicted model O14246: TM-score 0.68, RMSD 1.93 Å
- 5WE0 chain E against the predicted model O14246: TM-score 0.61, RMSD 2.36 Å
- 5WE0 chain E against the predicted model O14246: TM-score 0.61, RMSD 2.36 Å
- 5WE2 chain D against the predicted model O14246: TM-score 0.61, RMSD 2.33 Å
- 5WE2 chain D against the predicted model O14246: TM-score 0.61, RMSD 2.33 Å
- 5XXE chain C against the predicted model O14246: TM-score 0.61, RMSD 2.46 Å
- 5XXE chain C against the predicted model O14246: TM-score 0.61, RMSD 2.46 Å
- 5XXF chain C against the predicted model O14246: TM-score 0.60, RMSD 2.56 Å
- 5XXF chain C against the predicted model O14246: TM-score 0.60, RMSD 2.56 Å
Elsewhere
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