MolNFT v1 · #138280 · protein
Structural basis for shelterin bridge assembly
5WE1 · Protection of telomeres protein POZ1,PROTECTION of…: “Structural basis for shelterin bridge assembly”. X-ray diffraction, 1 ligand (ZN), 8 pockets (best druggability 0.56). MolNFT v1 #138280 on GenesisL1: 3D structure, binding sites…
- PDB
- 5WE1
- Type
- protein
- Length
- 417 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protection of telomeres protein POZ1,PROTECTION of telomeres protein POZ1; Protection of…
- UniProt
- O13852, O14246
- Ligands
- ZN
- Pockets
- 8 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protection of telomeres protein POZ1,PROTECTION of telomeres protein POZ1 | protein | 178 | 67% helix, 0% strand | O13852 |
| B | Protection of telomeres protein TPZ1 | protein | 29 | 72% helix, 0% strand | O14246 |
| C | Protection of telomeres protein POZ1,PROTECTION of telomeres protein POZ1 | protein | 180 | 70% helix, 0% strand | O13852 |
| D | Protection of telomeres protein TPZ1 | protein | 30 | 70% helix, 0% strand | O14246 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.56 | 0.80 | 20 | empty |
| 2 | 58 | 0.53 | 0.87 | 15 | empty |
| 3 | 87 | 0.48 | 0.82 | 17 | empty |
| 4 | 183 | 0.45 | 0.75 | 28 | empty |
| 5 | 141 | 0.44 | 0.76 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1051 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 1049 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1022 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 171 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 125 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5WE1 · Structural Basis for Shelterin Bridge Assembly · the same entry in another collection · chain C against C, TM-score 1.00
- O13852 · AlphaFold monomer V2.0 prediction for protection of telomeres protein POZ1 (O13852) · a predicted model of the same protein · chain A against A, TM-score 0.93
- O14246 · AlphaFold monomer V2.0 prediction for protection of telomeres protein TPZ1 (O14246) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13852
- Every structure of UniProt O14246
- Elsewhere: RCSB PDB 5WE1 · PDBe 5WE1 · UniProt O13852 · UniProt O14246
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