MolNFT v1 · #140020 · protein
Crystal structure of POZ1 and TPZ1
5XXE · Protection of telomeres protein POZ1: “Crystal structure of POZ1 and TPZ1”. X-ray diffraction, 2 ligands (ZN, SO4), 6 pockets (best druggability 0.36). MolNFT v1 #140020 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5XXE
- Type
- protein
- Length
- 509 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protection of telomeres protein POZ1; Protection of telomeres protein TPZ1
- UniProt
- O13852, O14246
- Ligands
- ZN, SO4
- Pockets
- 6 · best druggability 0.36
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protection of telomeres protein POZ1 | protein | 220 | 73% helix, 0% strand | O13852 |
| C, D | Protection of telomeres protein TPZ1 | protein | 32 | 72% helix, 0% strand | O14246 |
| B | Protection of telomeres protein POZ1 | protein | 225 | 74% helix, 0% strand | O13852 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, C, B, D
- SO4 · Sulfate ion · ion · 10 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.36 | 0.75 | 18 | empty |
| 2 | 89 | 0.36 | 0.75 | 16 | SO4 |
| 3 | 67 | 0.35 | 0.77 | 15 | empty |
| 4 | 55 | 0.31 | 0.76 | 13 | empty |
| 5 | 61 | 0.29 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1267 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 1265 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 755 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified (engineered).
Compared structures
- 5XXE · Crystal structure of Poz1 and Tpz1 · the same entry in another collection · chain A against A, TM-score 1.00
- O13852 · AlphaFold monomer V2.0 prediction for protection of telomeres protein POZ1 (O13852) · a predicted model of the same protein · chain B against A, TM-score 0.96
- O14246 · AlphaFold monomer V2.0 prediction for protection of telomeres protein TPZ1 (O14246) · a predicted model of the same protein · chain C against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13852
- Every structure of UniProt O14246
- Elsewhere: RCSB PDB 5XXE · PDBe 5XXE · UniProt O13852 · UniProt O14246
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