MolNFT v1 · #175561 · protein
Crystal structure of fission yeast POT1 and TPZ1
7CUI · Protection of telomeres protein 1: “Crystal structure of fission yeast POT1 and TPZ1”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.70). MolNFT v1 #175561 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7CUI
- Type
- protein
- Length
- 402 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protection of telomeres protein 1; Protection of telomeres protein TPZ1
- UniProt
- O13988, O14246
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protection of telomeres protein 1 | protein | 173 | 30% helix, 34% strand | O13988 |
| B, D | Protection of telomeres protein TPZ1 | protein | 28 | 57% helix, 0% strand | O14246 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.70 | 0.82 | 31 | empty |
| 2 | 54 | 0.26 | 0.73 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1259 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1254 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 648 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 7CUI · Crystal structure of fission yeast Pot1 and Tpz1 · the same entry in another collection · chain A against A, TM-score 1.00
- O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.92
- O14246 · AlphaFold monomer V2.0 prediction for protection of telomeres protein TPZ1 (O14246) · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13988
- Every structure of UniProt O14246
- Elsewhere: RCSB PDB 7CUI · PDBe 7CUI · UniProt O13988 · UniProt O14246
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