UniProt O00757
Fructose-1,6-bisphosphatase isozyme 2 (O00757)
Fructose-1,6-bisphosphatase isozyme 2 (UniProt O00757), EC 3.1.3.11: 27 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00757
- Protein
- Fructose-1,6-bisphosphatase isozyme 2
- EC
- 3.1.3.11
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 25 · 3 records with a druggable one
Structures
28 records of O00757 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3IFA | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP | x-ray diffraction | A, B, C, D | — | — |
| 3IFA | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP | x-ray diffraction | A, B, C, D | — | — |
| 3IFC | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP and alpha… | x-ray diffraction | A, B, C, D | — | — |
| 3IFC | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP and alpha… | x-ray diffraction | A, B, C, D | — | — |
| 4HE0 | Crystal structure of human muscle fructose-1,6-bisphosphatase | x-ray diffraction | A | — | — |
| 4HE0 | Crystal structure of human muscle fructose-1,6-bisphosphatase | x-ray diffraction | A | — | — |
| 4HE1 | Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with… | x-ray diffraction | A | — | — |
| 4HE1 | Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with… | x-ray diffraction | A | — | — |
| 4HE2 | Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP | x-ray diffraction | A | — | — |
| 4HE2 | Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP | x-ray diffraction | A | — | — |
| 5ET5 | Human muscle fructose-1,6-bisphosphatase in active R-state | x-ray diffraction | A | — | — |
| 5ET5 | Human muscle fructose-1,6-bisphosphatase in active R-state | x-ray diffraction | A | — | — |
| 5ET6 | Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP | x-ray diffraction | A, C, B, D | AMP | 20 (best 0.68) |
| 5ET6 | Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP | x-ray diffraction | A, C, B, D | — | — |
| 5ET7 | Human muscle fructose-1,6-bisphosphatase in inactive T-state | x-ray diffraction | A, C, B, D | — | — |
| 5ET7 | Human muscle fructose-1,6-bisphosphatase in inactive T-state | x-ray diffraction | A, C, B, D | — | — |
| 5ET8 | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate | x-ray diffraction | A | F6P | 2 (best 0.51) |
| 5ET8 | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate | x-ray diffraction | A | — | — |
| 5K54 | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state | x-ray diffraction | A | — | — |
| 5K54 | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state | x-ray diffraction | A | — | — |
| 5K55 | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with… | x-ray diffraction | A | F6P | 3 (best 0.55) |
| 5K55 | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with… | x-ray diffraction | A | F6P | — |
| 5K56 | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate | x-ray diffraction | A | FBP | — |
| 5K56 | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate | x-ray diffraction | A | FBP | — |
| 5L0A | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with… | x-ray diffraction | A | FBP | — |
| 5L0A | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with… | x-ray diffraction | A | FBP | — |
| 5Q0C | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 96G, FDP | — |
| O00757 | AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase isozyme 2 (O00757) | predicted | A | — | — |
Ligands
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 4 records
- F6P · 6-O-phosphono-beta-D-fructofuranose · in 3 records
- 96G · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- FDP · 2,6-di-O-phosphono-beta-D-fructofuranose · in 1 record
Experiment against prediction
- 4HE1 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.49 Å
- 4HE1 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.49 Å
- 5ET7 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.49 Å
- 5ET7 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.49 Å
- 4HE2 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.50 Å
- 4HE2 chain A against the predicted model O00757: TM-score 0.99, RMSD 0.50 Å
- 5ET7 chain D against the predicted model O00757: TM-score 0.99, RMSD 0.51 Å
- 5ET7 chain D against the predicted model O00757: TM-score 0.99, RMSD 0.51 Å
- 5ET7 chain B against the predicted model O00757: TM-score 0.99, RMSD 0.55 Å
- 5ET7 chain B against the predicted model O00757: TM-score 0.99, RMSD 0.55 Å
Elsewhere
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