MolNFT v1 · #118148 · protein

Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate

5ET8 · Fructose-1,6-bisphosphatase isozyme 2: “Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate”. X-ray diffraction, 1 ligand (F6P), 2 pockets (best druggability 0.51). MolNFT v1 #118148 on…

PDB: 5ET8
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-1,6-bisphosphatase isozyme 2
EC: 3.1.3.11
UniProt: O00757
Ligands: F6P
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11)	protein	287	37% helix, 26% strand	O00757

Ligands and binding sites

F6P · 6-O-phosphono-beta-D-fructofuranose · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	200	0.51	0.76	23	empty
2	70	0.32	0.75	17	F6P

Compared structures

5ET8 · Human muscle fructose-1,6-bisphosphatase in active R-state in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
O00757 · AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase isozyme 2 (O00757) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00757
Elsewhere: RCSB PDB 5ET8 · PDBe 5ET8 · UniProt O00757

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.