MolNFT v1 · #118147 · protein
Human muscle fructose-1,6-bisphosphatase in inactive T-state
5ET7 · Fructose-1,6-bisphosphatase isozyme 2: “Human muscle fructose-1,6-bisphosphatase in inactive T-state”. X-ray diffraction, 17 pockets (best druggability 0.61). MolNFT v1 #118147 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5ET7
- Type
- protein
- Length
- 1,118 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-1,6-bisphosphatase isozyme 2
- EC
- 3.1.3.11
- UniProt
- O00757
- Pockets
- 17 · best druggability 0.61
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) | protein | 287 | 36% helix, 27% strand | O00757 |
| C | Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) | protein | 278 | 34% helix, 28% strand | O00757 |
| B | Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) | protein | 280 | 36% helix, 28% strand | O00757 |
| D | Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) | protein | 273 | 35% helix, 28% strand | O00757 |
Pockets
17 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.61 | 0.88 | 27 | empty |
| 2 | 227 | 0.60 | 0.81 | 34 | empty |
| 3 | 247 | 0.50 | 0.75 | 23 | empty |
| 4 | 90 | 0.45 | 0.80 | 17 | empty |
| 5 | 75 | 0.41 | 0.79 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 965 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 695 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 640 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5ET7 · Human muscle fructose-1,6-bisphosphatase in inactive T-state · the same entry in another collection · chain D against D, TM-score 1.00
- O00757 · AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase isozyme 2 (O00757) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00757
- Elsewhere: RCSB PDB 5ET7 · PDBe 5ET7 · UniProt O00757
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