MolNFT v1 · #124092 · protein
Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state
5K54 · Fructose-1,6-bisphosphatase isozyme 2: “Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #124092 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5K54
- Type
- protein
- Length
- 283 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-1,6-bisphosphatase isozyme 2
- EC
- 3.1.3.11
- UniProt
- O00757
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) | protein | 283 | 34% helix, 26% strand | O00757 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.55 | 0.79 | 22 | empty |
| 2 | 113 | 0.41 | 0.76 | 21 | empty |
Compared structures
- 5K54 · Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state · the same entry in another collection · chain A against A, TM-score 1.00
- O00757 · AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase isozyme 2 (O00757) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00757
- Elsewhere: RCSB PDB 5K54 · PDBe 5K54 · UniProt O00757
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