UniProt K9N638
3C-like proteinase nsp5 (K9N638)
3C-like proteinase nsp5 (UniProt K9N638), EC 3.4.22.69: 12 experimental structures on GenesisL1, 15 ligands bound, 15 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- K9N638
- Protein
- 3C-like proteinase nsp5
- EC
- 3.4.22.69
- Experimental structures
- 12
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 15 · 5 records with a druggable one
Structures
12 records of K9N638 in the MolNFT archive: 12 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3D | Crystal structure of MERS Coronavirus papain like protease | x-ray diffraction | B, A | — | — |
| 4R3D | Crystal structure of MERS coronavirus papain like protease | x-ray diffraction | B, A | — | — |
| 7T3Y | Structure of MERS 3CL protease in complex with inhibitor 8C | x-ray diffraction | A, B | F5L, F8C | — |
| 7T3Z | Structure of MERS 3CL protease in complex with inhibitor 9C | x-ray diffraction | A, B | FHS, FEY | — |
| 7T40 | Structure of MERS 3CL protease in complex with inhibitor 10c | x-ray diffraction | A | FV5, FVE | — |
| 7T40 | Structure of MERS 3CL protease in complex with inhibitor 10C | x-ray diffraction | A | FV5, FVE | — |
| 7T41 | Structure of MERS 3CL protease in complex with inhibitor 14C | x-ray diffraction | A | FWI, FZI | — |
| 8R5J | Crystal structure of MERS-CoV main protease | x-ray diffraction | A, B | — | 5 (best 0.77) |
| 9ATA | Crystal structure of MERS 3CL protease in complex with a phenylethyl 2-pyrrolidone inhibitor | x-ray diffraction | A, B | A1AGG, A1AGH | 4 (best 0.85) |
| 9ATD | Crystal structure of MERS 3CL protease in complex with a ethylcyclohexyl 2-pyrrolidone inhibitor… | x-ray diffraction | A | A1AGL, A1AGK | 2 (best 0.54) |
| 9ATI | Crystal structure of MERS 3CL protease in complex with a racemic bicyclo[2.2.1]heptenyl-methyl… | x-ray diffraction | A | A1AGV, A1AGU | 2 (best 0.52) |
| 9BOO | Crystal structure of MERS-CoV Nsp5 in complex with PF-07817883 | x-ray diffraction | A | YDL | 2 (best 0.55) |
Ligands
- FV5 · (1R,2S)-1-hydroxy-2-{[N-({[7-(methanesulfonyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 2 records
- FVE · (1S,2S)-1-hydroxy-2-{[N-({[7-(methanesulfonyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 2 records
- A1AGG · (1S,2S)-1-hydroxy-2-{[N-({[(2S)-5-oxo-1-(2-phenylethyl)pyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- A1AGH · (1R,2S)-1-hydroxy-2-{[N-({[(2S)-5-oxo-1-(2-phenylethyl)pyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- A1AGK · (1R,2S)-2-{[N-({[(2S)-1-(2-cyclohexylethyl)-5-oxopyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- A1AGL · (1S,2S)-2-{[N-({[(2S)-1-(2-cyclohexylethyl)-5-oxopyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- A1AGU · (1R,2S)-2-{[N-({[(3S)-1-{[(1R,2R,4R)-bicyclo[2.2.1]hept-5-en-2-yl]methyl}-5-oxopyrrolidin-3-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- A1AGV · (1S,2S)-2-{[N-({[(3S)-1-{[(1R,2R,4R)-bicyclo[2.2.1]hept-5-en-2-yl]methyl}-5-oxopyrrolidin-3-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- F5L · (1R,2S)-1-hydroxy-2-{[N-({[7-(2-methylpropanoyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- F8C · (1S,2S)-1-hydroxy-2-{[N-({[7-(2-methylpropanoyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- FEY · (1R,2S)-2-{[N-({[(2R,4R)-7-acetyl-7-azaspiro[3.5]non-5-en-2-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid · in 1 record
- FHS · (1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-{[N-({[7-(phenylacetyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}propane-1-sulfonic acid · in 1 record
- FWI · (1R,2S)-2-{[N-({[1-(tert-butoxycarbonyl)azetidin-3-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3R)-2-oxo-2,3-dihydro-1H-pyrrol-3-yl]propane-1-sulfonic acid · in 1 record
- FZI · (1S,2S)-2-{[N-({[1-(tert-butoxycarbonyl)azetidin-3-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3R)-2-oxo-2,3-dihydro-1H-pyrrol-3-yl]propane-1-sulfonic acid · in 1 record
- YDL · N-(methoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-(trifluoromethyl)-L-prolinamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.