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Ligand · F5L

F5L · (1R,2S)-1-hydroxy-2-{[N-({[7-(2-methylpropanoyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid

F5L, (1R,2S)-1-hydroxy-2-{[N-({[7-(2-methylpropanoyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (C26 H44 N4 O9 S, 588.7 g/mol), in the MolNFT structures on GenesisL1: bound…

Component
F5L
Formula
C26 H44 N4 O9 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

F5L in 2 structures; the first of them:

  • 7T3Y · Structure of MERS 3CL protease in complex with inhibitor 8C · F5L A401 · binds HIS41, LEU49, PHE143, LEU144, CYS145, SER147, CYS148, HIS166 and 8 more
  • 7T46 · Structure of SARS-cov-2 3CL protease in complex with inhibitor 8C · F5L A402 · binds HIS41, PHE140, ASN142, SER144, CYS145, HIS163, HIS164, MET165 and 7 more

Residues it binds most

HIS 4, GLN 4, LEU 4, CYS 4, MET 4, ASP 4, GLU 4, PHE 4, SER 4, ARG 2 (residue and the binding sites it lines).

Found with

  • F8C · (1S,2S)-1-hydroxy-2-{[N-({[7-(2-methylpropanoyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid

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