UniProt F1QCV2
Polyamine deacetylase HDAC10 (F1QCV2)
Polyamine deacetylase HDAC10 (UniProt F1QCV2), EC 3.5.1.48, 3.5.1.62: 33 experimental structures and 1 predicted model on GenesisL1, 29 ligands bound, 51 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- F1QCV2
- Protein
- Polyamine deacetylase HDAC10
- EC
- 3.5.1.48, 3.5.1.62
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 29
- Pockets
- 51 · 8 records with a druggable one
Structures
34 records of F1QCV2 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UFN | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | Q6M, ZN, PO4, K | — |
| 6UFO | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with… | x-ray diffraction | A | Q6P, ZN, PO4, K | 7 (best 0.71) |
| 6UFO | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | Q6P, ZN, PO4, K | — |
| 6UHU | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | Q7V, ZN, PO4, K | — |
| 6UHV | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with… | x-ray diffraction | A | XS6, ZN, K, PO4 | — |
| 6UHV | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | XS6, ZN, K, PO4 | — |
| 6UII | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | SS9, ZN, K, PO4 | — |
| 6UIJ | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | SS9, ZN, PO4, K | — |
| 6UIL | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | FKS, PO4, ZN, K | — |
| 6UIM | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with… | x-ray diffraction | A | Q7Y, ZN, PO4, K | 7 (best 0.68) |
| 6UIM | Crystal structure of danio rerio histone deacetylase 10 in complex with… | x-ray diffraction | A | Q7Y, ZN, PO4, K | — |
| 6VNQ | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Bishydroxamic Acid Based… | x-ray diffraction | A | R5G, ZN, K, PO4 | — |
| 6VNQ | Crystal structure of danio rerio histone deacetylase 10 in complex with bishydroxamic acid based… | x-ray diffraction | A | R5G, ZN, K, PO4 | — |
| 6WBQ | Crystal structure of danio rerio histone deacetylase 10 in complex with tubastatin a | x-ray diffraction | A | N9W, K, PO4, ZN | — |
| 6WDV | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Dimethylaminomethylindole… | x-ray diffraction | A | TWM, PO4, ZN, K | 5 (best 0.64) |
| 6WDV | Crystal structure of danio rerio histone deacetylase 10 in complex with dimethylaminomethylindole… | x-ray diffraction | A | TWM, PO4, ZN, K | — |
| 6WDW | Crystal structure of danio rerio histone deacetylase 10 in complex with dimethylaminoethylindole… | x-ray diffraction | A | TWV, ZN, PO4, K | — |
| 6WDX | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Hydroxyethylindole… | x-ray diffraction | A | TWS, ZN, PO4, K | 7 (best 0.62) |
| 6WDX | Crystal structure of danio rerio histone deacetylase 10 in complex with hydroxyethylindole… | x-ray diffraction | A | TWS, ZN, PO4, K | — |
| 6WDY | Crystal structure of danio rerio histone deacetylase 10 in complex with indole phenylhydroxamate… | x-ray diffraction | A | TWP, ZN, PO4, K | — |
| 7KUQ | Crystal structure of danio rerio histone deacetylase 10 Y307F mutant in complex with… | x-ray diffraction | A | Q9C, ZN, K, PO4, NA | — |
| 7KUR | Crystal structure of danio rerio histone deacetylase 10 Y307F mutant in complex with… | x-ray diffraction | A | X5A, ZN, K, PO4 | — |
| 7KUS | Crystal structure of danio rerio histone deacetylase 10 H137A mutant in complex with… | x-ray diffraction | A | X54, ZN, K, PO4 | — |
| 7KUT | Crystal structure of danio rerio histone deacetylase 10 H137A mutant in complex with… | x-ray diffraction | A | X51, ZN, K, PO4 | — |
| 7KUV | Crystal structure of danio rerio histone deacetylase 10 in complex with acetate | x-ray diffraction | A | ZN, K, PO4 | — |
| 7SGK | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728 | x-ray diffraction | A | 9A9, ZN, K, PO4, NA | 7 (best 0.71) |
| 7U3M | Crystal structure of danio rerio histone deacetylase 10 in complex with N-methylpiperazine… | x-ray diffraction | A | L8C, ZN, K, PO4 | — |
| 7U59 | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Piperidine-4-hydroxamic… | x-ray diffraction | A | LDI, ZN, K, PO4, NA | 6 (best 0.66) |
| 7U69 | Crystal structure of danio rerio histone deacetylase 10 in complex with phenethyl… | x-ray diffraction | A | LS6, K, ZN, PO4 | — |
| 7U6A | Crystal structure of danio rerio histone deacetylase 10 in complex with 3-thienylmethyl… | x-ray diffraction | A | LSL, K, ZN, PO4 | — |
| 7U6B | Crystal structure of danio rerio histone deacetylase 10 in complex with indolethyl… | x-ray diffraction | B | LTO, K, ZN, PO4 | — |
| 9CBF | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminomethyl… | x-ray diffraction | A | A1AVR, PO4, K, ZN | 6 (best 0.61) |
| 9CBG | Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminoethyl… | x-ray diffraction | A | A1AVN, PO4, ZN, K | 6 (best 0.65) |
| F1QCV2 | AlphaFold monomer V2.0 prediction for polyamine deacetylase HDAC10 (F1QCV2) | predicted | A | — | — |
Ligands
- K · Potassium ion · in 33 records
- PO4 · Phosphate ion · in 33 records
- ZN · Zinc ion · in 33 records
- NA · Sodium ion · in 3 records
- Q6P · 7-[(3-aminopropyl)amino]-1-methoxyheptane-2,2-diol · in 2 records
- Q7Y · 7-[(3-aminopropyl)amino]-1-sulfanylheptan-2-one · in 2 records
- R5G · N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide · in 2 records
- SS9 · 5-[(3-aminopropyl)amino]pentane-1-thiol · in 2 records
- TWM · 4-({3-[(dimethylamino)methyl]-1H-indol-1-yl}methyl)-N-hydroxybenzamide · in 2 records
- TWS · N-hydroxy-4-{[3-(2-hydroxyethyl)-1H-indol-1-yl]methyl}benzamide · in 2 records
- XS6 · 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide · in 2 records
- 9A9 · N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide · in 1 record
- A1AVN · 1-[3-(2-aminoethyl)phenyl]-2-sulfanylethan-1-one · in 1 record
- A1AVR · 1-[3-(aminomethyl)phenyl]-2-sulfanylethan-1-one · in 1 record
- FKS · 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol · in 1 record
- L8C · N-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]benzamide · in 1 record
- LDI · 1-[2-(benzylamino)ethyl]-N-hydroxypiperidine-4-carboxamide · in 1 record
- LS6 · (2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide · in 1 record
- LSL · N-hydroxy-4-({[(thiophen-3-yl)methyl]amino}methyl) benzamide · in 1 record
- LTO · (2E)-N-hydroxy-3-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}prop-2-enamide · in 1 record
- N9W · 4-[(2-methyl-3,4-dihydro-1~{H}-pyrido[4,3-b]indol-5-yl)methyl]-~{N}-oxidanyl-benzamide · in 1 record
- Q6M · 7-[(3-aminopropyl)amino]heptane-2,2-diol · in 1 record
- Q7V · 5-(3-azanylpropylamino)pentyl-$L^{3}-oxidanyl-bis(oxidanyl)boron · in 1 record
- Q9C · N-{4-[(3-aminopropyl)amino]butyl}acetamide · in 1 record
- TWP · N-hydroxy-4-[(1H-indol-1-yl)methyl]benzamide · in 1 record
- TWV · 4-({3-[2-(dimethylamino)ethyl]-1H-indol-1-yl}methyl)-N-hydroxybenzamide · in 1 record
- X51 · 1-[(4-aminobutyl)amino]ethane-1,1-diol · in 1 record
- X54 · 1-({4-[(3-aminopropyl)amino]butyl}amino)ethane-1,1-diol · in 1 record
- X5A · N-(4-aminobutyl)acetamide · in 1 record
Experiment against prediction
- 7KUS chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.31 Å
- 7KUT chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.33 Å
- 7SGK chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.35 Å
- 7U3M chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.35 Å
- 7KUR chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.35 Å
- 7KUV chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.36 Å
- 7KUQ chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.36 Å
- 6UHV chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.35 Å
- 6UHV chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.35 Å
- 6WDW chain A against the predicted model F1QCV2: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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