UniProt B6DRA0
Capsid protein p24 (B6DRA0)
Capsid protein p24 (UniProt B6DRA0): 87 experimental structures on GenesisL1, 13 ligands bound, 216 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- B6DRA0
- Protein
- Capsid protein p24
- Experimental structures
- 87
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 216 · 10 records with a druggable one
Structures
87 records of B6DRA0 in the MolNFT archive: 87 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MCX | The structure of the mature HIV-1 CA hexamer in intact virus particles | electron microscopy | A, B, C, D, E, F, I, J, K, U, V, W, Z, b, R, c, G, S, L, N, P, O, Q, Y | — | 20 (best 0.42) |
| 5MCX | The structure of the mature HIV-1 ca hexamer in intact virus particles | electron microscopy | A, B, C, D, E, F, I, J, K, U, V, W, Z, b, R, c, G, S, L, N, P, O, Q, Y | — | — |
| 5MCY | The structure of the mature HIV-1 CA pentamer in intact virus particles | electron microscopy | A, B, F, R, S, T, P, Q, M, N, O, G, d, g, b, e, h, Z, c, f | — | — |
| 5MCY | The structure of the mature HIV-1 ca pentamer in intact virus particles | electron microscopy | A, B, F, R, S, T, P, Q, M, N, O, G, d, g, b, e, h, Z, c, f | — | — |
| 5UP4 | Structure of the HIV-1 capsid protein and spacer peptide 1 by cryo-EM | electron microscopy | B, K, L, M, N, O, P, Q, R, S, C, D, E, F, G, H, I, J | — | — |
| 5W4O | Structure of the R18A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 5W4O | Structure of the R18A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 5W4P | Structure of the E28A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 5W4Q | Structure of the R18A/E28A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 5W4Q | Structure of the R18A/E28A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXR | Structure of the P122A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | 2 (best 0.36) |
| 6AXR | Structure of the P122A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXS | Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXT | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | 2 (best 0.36) |
| 6AXT | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXV | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074… | x-ray diffraction | A | IOD, CL, 1B0 | 2 (best 0.35) |
| 6AXV | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with pf-3450074… | x-ray diffraction | A | IOD, CL, 1B0 | — |
| 6AXW | Structure of the I124A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXW | Structure of the I124A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXX | Structure of the T58A/I124A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXX | Structure of the T58A/I124A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AXY | Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6AY9 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide | x-ray diffraction | A | IOD, CL | 1 (best 0.38) |
| 6AY9 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide | x-ray diffraction | A | IOD, CL | — |
| 6B2G | P38A mutant of HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | 2 (best 0.34) |
| 6B2G | P38A mutant of HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6B2H | P38A/T216I mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | 2 (best 0.37) |
| 6B2H | P38A/T216I mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6B2I | E45A mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6B2J | E45A mutant of HIV-1 capsid protein (other crystal form) | x-ray diffraction | A | IOD, CL | — |
| 6B2J | E45A mutant of HIV-1 capsid protein (other crystal form) | x-ray diffraction | A | IOD, CL | — |
| 6B2K | E45A/R132T mutant of HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | 2 (best 0.33) |
| 6B2K | E45A/R132T mutant of HIV-1 capsid protein | x-ray diffraction | A | IOD, CL | — |
| 6ERM | HIV hexamer with ligand | x-ray diffraction | A | AZT | — |
| 6ERN | HIV Hexamer with ligand | x-ray diffraction | A | ATP | 1 (best 0.33) |
| 6ERN | HIV hexamer with ligand | x-ray diffraction | A | ATP | — |
| 6MQA | Structure of HIV-1 CA P207S | x-ray diffraction | A | IOD, CL | — |
| 6MQA | Structure of HIV-1 ca P207S | x-ray diffraction | A | IOD, CL | — |
| 6MQO | Structure of HIV-1 ca G208R | x-ray diffraction | A | IOD | — |
| 6MQP | Structure of HIV-1 CA T210K | x-ray diffraction | A | IOD, CL | 2 (best 0.34) |
| 6MQP | Structure of HIV-1 ca T210K | x-ray diffraction | A | IOD, CL | — |
| 6OBH | Structure of HIV-1 CA 1/2-hexamer | x-ray diffraction | B, E | NA | 12 (best 0.69) |
| 6OBH | Structure of HIV-1 ca 1/2-hexamer | x-ray diffraction | B, E | NA | — |
| 6OMT | HIV-1 capsid hexamer R18D mutant | x-ray diffraction | A | — | — |
| 6PU1 | Cysteine stabilized hexameric HIV-1 CA in complex with SEC24C peptide | x-ray diffraction | A | IOD, CL | 2 (best 0.30) |
| 6PU1 | Cysteine stabilized hexameric HIV-1 ca in complex with SEC24C peptide | x-ray diffraction | A | IOD, CL | — |
| 6R6Q | HIV capsid hexamer with IP5 ligand | x-ray diffraction | A | — | 1 (best 0.39) |
| 6R6Q | HIV capsid hexamer with IP5 ligand | x-ray diffraction | A | — | — |
| 6R8C | HIV capsid hexamer with IP5 ligand | x-ray diffraction | A | 5MY | 1 (best 0.37) |
| 6R8C | HIV capsid hexamer with IP5 ligand | x-ray diffraction | A | 5MY | — |
| 6V2F | Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor… | x-ray diffraction | A, B, C, D, E, F | QNG | — |
| 6V2F | Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor… | x-ray diffraction | A, B, C, D, E, F | QNG | — |
| 6VKV | Co-crystal structure of gs-6207 bound to HIV-1 capsid hexamer | x-ray diffraction | A, B, C | QNG, IOD, CL | — |
| 6VWS | Hexamer of helical HIV capsid by rastr method | electron microscopy | A, B, C, D, M, N | — | — |
| 7MKC | N74D mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74) | x-ray diffraction | A | 1B0, IOD | 2 (best 0.36) |
| 7MKC | N74D mutant of the HIV-1 capsid protein in complex with pf-3450074 (PF74) | x-ray diffraction | A | 1B0, IOD | — |
| 7MN0 | N74D mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD | 2 (best 0.34) |
| 7MN0 | N74D mutant of the HIV-1 capsid protein | x-ray diffraction | A | IOD | — |
| 7N9U | CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions | x-ray diffraction | A, B, C | — | 9 (best 0.68) |
| 7N9U | Ca-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions | x-ray diffraction | A, B, C | — | — |
27 records more on the page itself.
Ligands
- IOD · Iodide ion · in 49 records
- CL · Chloride ion · in 44 records
- QNG · N-[(1S)-1-(3-{4-chloro-3-[(methylsulfonyl)amino]-1-(2, 2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-methyl-3-(methylsulfonyl)but-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3bs,4ar)-5,5-difluoro-3-(trifluoromethyl)-3B,4,4A,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide · in 7 records
- 1B0 · N-methyl-nalpha-[(2-methyl-1H-indol-3-yl)acetyl]-N-phenyl-L-phenylalaninamide · in 4 records
- MYR · Myristic acid · in 4 records
- 5MY · Myo-inositol-(1,3,4,5,6)-pentakisphosphate · in 2 records
- 61F · N-[(1S)-1-(3-{4-chloro-3-[(methanesulfonyl)amino]-1-(2, 2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-(methanesulfonyl)-3-methylbut-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[3-(trifluoromethyl)-4, 5,6,7-tetrahydro-1H-indazol-1-yl]acetamide · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- IHP · Inositol hexakisphosphate · in 2 records
- NA · Sodium ion · in 2 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 2 records
- AZT · 3'-azido-3'-deoxythymidine-5'-triphosphate · in 1 record
- Y05 · N-[(1S)-1-{(3P)-3-{4-chloro-3-[(methanesulfonyl)amino]-1-methyl-1H-indazol-7-yl}-7-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-oxo-3,4-dihydroquinazolin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide · in 1 record
Elsewhere
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