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Ligand · AZT

AZT · 3'-azido-3'-deoxythymidine-5'-triphosphate

AZT, 3'-azido-3'-deoxythymidine-5'-triphosphate (C10 H16 N5 O13 P3, 507.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
AZT
Formula
C10 H16 N5 O13 P3
Class
ligand
Structures
4
PDB entries
3

Binding sites

AZT in 4 structures; the first of them:

  • 5I42 · Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+)… · AZT A602 · binds LYS65, LYS70, ARG72, ASP110, VAL111, GLY112, ASP113, ALA114 and 9 more
  • 8ICO · DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked… · AZT A338 · binds DG7, ARG149, GLY179, SER180, ARG183, SER187, SER188, GLY189 and 7 more
  • 6ERM · HIV hexamer with ligand · AZT A301 · binds ARG18
  • 8ICO · DNA polymerase beta (pol B) (E.C.2.7.7.7) complexed with seven base pairs of DNA; soaked… · AZT A338 · binds DG7, ARG149, GLY179, SER180, ARG183, SER187, SER188, GLY189 and 6 more

Residues it binds most

ASP 4, GLY 4, ARG 5, LYS 2, SER 2, DG 4, PHE 4, TYR 4, ALA 2, DA 2 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • NA · Sodium ion
  • CA · Calcium ion

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